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New study tests best strategy to stop kidney stones

NCT ID NCT05365477

Disease control Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at two different approaches to prevent kidney stones in adults who have had at least two stones in the past five years. One approach used diet and medication based on each person's test results, while the other used a standard one-size-fits-all plan. The goal was to see which method better reduced stone-forming substances in urine and was easier for people to follow.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

56 people

The number who actually took part.

Started

Aug 2022

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Two or more symptomatic kidney stone events in the last 5 years * Adult Exclusion Criteria: * Medullary sponge kidney or renal tubular acidosis * Untreated urinary obstruction * Primary hyperparathyroidism * Primary hyperoxaluria * Pregnancy * Inflammatory bowel disease or bowel resection * Sarcoidosis * Cystinuria * Prior stone composition with uric acid, struvite, cystine, carbonate apatite * Use of specific medications (thiazides, topiramate, xanthine oxidase inhibitors, citrate, bicarbonate) * Chronic kidney disease stage 3 or higher (eGFR\<60) * Gouty arthritis or 3 gout episodes in 1 year * Known allergy to study medications * Hypokalemia or hyponatremia at screening. * Age \< 18 years

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Conditions

The condition(s) this trial relates to.

Kidney Calculi nephrolithiasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Kidney stones Nephrolithiasis

Contacts and locations

Locations

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.