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Ketone drink may alter Post-Workout hormones, small study finds

NCT ID NCT06683547

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether drinking a ketone monoester supplement changes hormone levels in healthy young men after a single session of resistance exercise. Twelve participants did leg presses and curls, then had their blood tested for testosterone and growth hormone over four hours. The goal is to see if ketone supplements, which raise blood ketones without diet changes, can influence the natural hormone response to exercise.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ketone monoester supplement
What this could lead to
If successful, this could help us understand how ketone supplements might influence muscle-building hormones after exercise.
What could go wrong
This is a very small, early study with only 12 healthy young men. It looks at short-term hormone changes, not long-term health or muscle gains. Results may not apply to women, older adults, or people with health conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

12 people

The number who actually took part.

Started

Jan 2025

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy adult male participants who are 18-40 years of age (inclusive). * BMI \>18.5 and \<30.0 kg/m2 * Recreationally active (at least of 150 minutes of activity/week). * Has maintained stable use of medication and supplements (which are not limited by the exclusion criteria), stable dietary and lifestyle habits, and stable body weight, for the last 3 months prior to screening and agree to maintain them throughout the study. * Be willing to entirely avoid alcohol consumption 48 hours prior to the test days. * Willing and able to agree to the requirements and restrictions of this study, be willing to give voluntary consent, be able to understand and read the questionnaires, and carry out all study-related procedures. Exclusion Criteria: * Individuals with metabolic disorders including: Type I or Type II diabetes. * Individuals with a history of thrombosis / cardiovascular disease, endocrine disorders * Individuals with knee injuries (i.e., ACL injuries). * Individuals with a positive medical history of unstable thyroid disease (i.e., hypothyroidism, hyperthyroidism, hyperparathyroidism, and hypoparathyroidism) and immune disorders. * Individuals who have used tobacco products within the last 6 months. * Chronic usage of medications known to modulate hormone levels (i.e. corticosteroids and hormone replacement therapy (HRT)) in the last 6 months. * Current use of ketone supplements or adherence to a ketogenic diet. * Formal or regular weightlifting activity within the last year.

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Conditions

The condition(s) this trial relates to.

Ketosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • McGill University

    Montreal, Quebec, H2W 1S4, Canada

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