Ketone drink may alter Post-Workout hormones, small study finds
NCT ID NCT06683547
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested whether drinking a ketone monoester supplement changes hormone levels in healthy young men after a single session of resistance exercise. Twelve participants did leg presses and curls, then had their blood tested for testosterone and growth hormone over four hours. The goal is to see if ketone supplements, which raise blood ketones without diet changes, can influence the natural hormone response to exercise.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Ketone monoester supplement
- What this could lead to
- If successful, this could help us understand how ketone supplements might influence muscle-building hormones after exercise.
- What could go wrong
- This is a very small, early study with only 12 healthy young men. It looks at short-term hormone changes, not long-term health or muscle gains. Results may not apply to women, older adults, or people with health conditions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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12 people
The number who actually took part.
- Started
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Jan 2025
- Finished
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Jul 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 40 years
- Sex
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Male participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Healthy adult male participants who are 18-40 years of age (inclusive). * BMI \>18.5 and \<30.0 kg/m2 * Recreationally active (at least of 150 minutes of activity/week). * Has maintained stable use of medication and supplements (which are not limited by the exclusion criteria), stable dietary and lifestyle habits, and stable body weight, for the last 3 months prior to screening and agree to maintain them throughout the study. * Be willing to entirely avoid alcohol consumption 48 hours prior to the test days. * Willing and able to agree to the requirements and restrictions of this study, be willing to give voluntary consent, be able to understand and read the questionnaires, and carry out all study-related procedures. Exclusion Criteria: * Individuals with metabolic disorders including: Type I or Type II diabetes. * Individuals with a history of thrombosis / cardiovascular disease, endocrine disorders * Individuals with knee injuries (i.e., ACL injuries). * Individuals with a positive medical history of unstable thyroid disease (i.e., hypothyroidism, hyperthyroidism, hyperparathyroidism, and hypoparathyroidism) and immune disorders. * Individuals who have used tobacco products within the last 6 months. * Chronic usage of medications known to modulate hormone levels (i.e. corticosteroids and hormone replacement therapy (HRT)) in the last 6 months. * Current use of ketone supplements or adherence to a ketogenic diet. * Formal or regular weightlifting activity within the last year.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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McGill University
Montreal, Quebec, H2W 1S4, Canada
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