Ketone showdown: which supplement wins in the body?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * • Provide voluntary signed and dated informed consent. * Be in good health as determined by medical history and routine blood chemistries. * Age between 30 and 70 yr (inclusive). * Body Mass Index of 25-34.9 (inclusive). * Body weight of at least 120 pounds. * Normotensive (seated, resting systolic blood pressure \<140 mm Hg and diastolic blood pressure \< 90 mm Hg. If the first measurement is slightly elevated above these limits, the subject will be given a brief (5 minute) rest period, and two more measurements will be taken. The average of all three measurements will be used to determine eligibility. * Normal seated, resting heart rate (\<90 per minute). * Willing to duplicate and record their previous 24-hour diet, refrain from caffeine, alcohol and exercise for 24 hours prior to each visit, and fast for 10 hours prior to each visit. * Subject agrees to maintain existing dietary and physical activity patterns throughout the study period. * Subject is willing and able to comply with the study protocol. Exclusion Criteria: * Individuals using any kind of GLP-1 medications. * Individuals who are determined to have liver, renal, cardiovascular, neurological, or other metabolic disease. * History or presence of diabetes, prediabetes or endocrine disorder. * Use of any dietary supplements or medications which may confound the study or its endpoints (e.g., fish oil, choline donors, gingko biloba, phosphatidylserine, huperzine A, etc.). * Alcohol consumption (more than 2 standard alcoholic drinks per day or more than 10 drinks per week) or drug abuse or dependence within the past 6 months. * Current nicotine use \> 100 mg/day. * History of hyperparathyroidism or an untreated thyroid condition. * History of malignancy in the previous 5 years, except for non-melanoma skin cancer (basal cell cancer or squamous cell cancer of the skin). * History of chronic psychiatric conditions (e.g., bipolar, schizophrenia, PTSD, depression, etc.). * History of brain disorders \[e.g., stroke, MS, Parkinson's, history of TBI or epilepsy, migraine (\>1 migraine per month), etc.\]. * Prior gastrointestinal bypass surgery (Lapband), etc. * Other known gastrointestinal or metabolic conditions that might impact nutrient absorption or metabolism, e.g., short bowel syndrome, Inflammatory bowel syndrome (IBS), Inflammatory bowel disease (IBD; e.g., Crohn's, ulcerative colitis), diarrheal illnesses, history of colon resection, gastro paresis, Inborn-Errors-of-Metabolism (such as PKU). * Chronic inflammatory condition (e.g., rheumatoid arthritis, Lupus, HIV/AIDS, etc.). * Previous medical diagnosis of asthma, gout, or fibromyalgia. * Currently following a low-carbohydrate, keto type diet, or practicing an intermittent fasting lifestyle (\>14 hours of fasting). * Subjects that have donated blood or plasma within the previous week. * Pregnant women, women trying to become pregnant, women less than 120 days postpartum or nursing women. Women who participate in this study must agree to the use of contraception for the duration of the study and any woman that is sexually active will have to take pregnancy test prior to enrolling with a negative result. Women of childbearing age (any woman prior to menopause) regardless of their use of contraception will be provided a urine pregnancy test kit at their screening visit and take the test in private using the female lavatory after signing an informed consent. * Known sensitivity to any ingredient in the test formulations as listed in the product label. * Currently participating in another research study with an investigational product or have been in another research study in the past 30 days. * Clinically significant abnormal laboratory results at screening. * Any other conditions that, in the opinion of the medical staff, could confound the primary endpoints or place the subject at increased risk of harm if they were to participate.