Ketamine shows promise for rapid relief of suicidal ideation
NCT ID NCT02299440
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether ketamine, given as two infusions, can quickly reduce suicidal thoughts in 156 hospitalized patients at high risk for suicide. The main goal was to see if suicidal ideas resolved within 24 hours after the second dose. The approach aims to provide fast, short-term relief during a crisis.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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156 people
The number who actually took part.
- Started
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Apr 2015
- Finished
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Nov 2019
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * French speaking patients freely hospitalized for prevention of suicide and who have a medium or high suicide risk score according to a MINI structured interview * The patient is able to understand how the study is carried out and the tests performed * The patient is deemed capable of giving his/her informed consent * The patient has been correctly informed * The patient must have given his/her informed and signed consent. * The patient must be insured or beneficiary of a health insurance plan. * Presence of suicidal ideation according to the SSI score (score \> 3) * Negative pregnancy test for women of childbearing age Exclusion Criteria: * The patient is participating in another interventional study * Within the past three months, the patient has participated in another interventional study * The patient is in an exclusion period determined by a previous study * The patient is under judicial protection * The patient is an adult under guardianship * The patient refuses to sign the consent * The patient is not able to understand the informed consent * Pregnancy or breastfeeding * History of schizophrenia or other psychotic disorders * Presence of psychotic symptoms at initial interview * Schizoid or schizotypic personality disorder * Positive urine screening for illicit substances, excluding cannabis * Substance dependence in the preceding month (excluding nicotine or caffeine) * Concomitant treatment with electroconvulsive therapy * Unstable somatic pathology * Clinically significant anomalies found during clinical examination, biological test or ECG * Non-stabilized hypertension or hypertension \> 180/100 * Known or suspected contra-indication for ketamine (includes interactions): hypersensitivity to ketamine, hypertension, class IV cardiac insufficiency, history of stroke, hepatic or cutaneous porphyria, history of intracranial hypertension
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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APHP - Hôpital Lariboisière
Paris, 75010, France
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CHRU de Lille - Hôpital Michel Fontan
Lille, 59037, France
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CHRU de Montpellier - Hôpital Lapeyronie
Montpellier, 34295, France
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CHRU de Nîmes - Hôpital Universitaire Carémeau
Nîmes, 30029, France
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CHRU de Tours - Clinique Psychiatrique Universitaire
Saint-Cyr-sur-Loire, 37540, France
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CHU de Clermont Ferrand - Hôpital Gabriel-Montpied
Clermont-Ferrand, 63003, France
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CMME Centre Hospitalier Sainte Anne
Paris, 75674, France
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Centre Hospitalier Sainte-Anne
Paris, 75674, France
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Clinique Les Sophoras
Nîmes, 30000, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a short, Family-Focused program replace hospital stays for suicidal teens?
- Can a website persuade men in crisis to ask for help?
- Can group therapy help teens with suicidal thoughts?
- Can music soothe the inner pain of a suicidal crisis?
- Can a single shot of ketamine calm suicidal distress in the ER?
- Can a centralized team prevent more suicide attempts?