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Could Children's discarded tissue hold the key to fixing arthritis?

NCT ID NCT06167928

Knowledge-focused Sponsor: Keele University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This observational study collects tissue samples from children undergoing surgery for polydactyly or hip dislocation, as well as from biobanks, to see which cells are best at forming cartilage. Researchers will test these cells in the lab and in animal models. The goal is to learn which tissues could lead to future treatments for cartilage and bone injuries and osteoarthritis. No new treatments are being tested on participants.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could point toward new cell-based therapies for repairing cartilage and bone damage, potentially helping people with osteoarthritis.
What could go wrong
This is an early observational study, not a treatment trial. It only looks at cells in the lab, so any future therapies are years away and may not work in humans.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 325 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2018

Expected to finish

Sep 2037

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Juvenile/infant donors: Participants between 0-4 years of age scheduled for polydactyly digit amputation or hip dislocation surgeries at the RJAH Orthopaedic, Alder Hey, Norwich and Norfolk, Royal National Orthopaedic and Birmingham Women's and Children's Hospitals (where appropriate i.e. polydactyly only at Alder Hey, and Norwich and Norfolk. Biobank/NHSBT donors: Participants of any age that have consented to donating their cartilage tissues to a bio-bank.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: For juvenile/infant donors: * Parents/guardians being able to provide signed and dated informed consent form. * Scheduled for one of the following surgical treatments: Digit amputations due to polydactyly. Surgery to treat dislocated hips. For biobank/NHSBT donors * Informed consent via consenting institution. Exclusion Criteria: * Parents/guardians not understanding the Patient Information Sheet

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Conditions

The condition(s) this trial relates to.

developmental dysplasia of the hip osteoarthritis polydactyly

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust

    RECRUITING

    Oswestry, Shropshrie, SY10 7AG, United Kingdom

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