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New pill for psoriasis shows promise in large trial

NCT ID NCT06934226

Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 28, 2026 · Updated 4 times

Summary

This Phase 3 trial tests an oral drug called JNJ-77242113 in 752 adults with moderate to severe plaque psoriasis. Participants receive either the new drug, a placebo, or an active comparator (Stelara). The study measures how well the drug clears skin lesions at 16 weeks. The goal is to see if this pill can offer a convenient, effective treatment option.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
JNJ-77242113 (an oral drug for psoriasis)
What this could lead to
If successful, this could offer a new oral treatment option for people with moderate to severe plaque psoriasis, potentially with fewer injections.
What could go wrong
This is an early Phase 3 trial, so results are not yet known. The drug may not work better than existing treatments or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

752 people

The number who actually took part.

Started

Apr 2025

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

12 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of plaque psoriasis, with or without psoriatic arthritis (PsA), prior to the first administration of study intervention * Total body surface area (BSA) greater than or equal to (\>=)10 percent (%) at screening and baseline * Total psoriasis area and severity index (PASI) \>=12 at screening and baseline * Total investigator global assessment (IGA) \>=3 at screening and baseline * Candidate for phototherapy or systemic treatment for plaque psoriasis Exclusion Criteria: * Nonplaque form of psoriasis (for example \[e.g.\], erythrodermic, guttate, or pustular) * Current drug-induced psoriasis (e.g., a new onset of psoriasis or an exacerbation of psoriasis from beta blockers, calcium channel blockers, or lithium) * Known allergies, hypersensitivity, or intolerance to JNJ-77242113, ustekinumab, or its excipients * Major surgical procedure within 8 weeks before screening, or will not have fully recovered from surgical procedure, or has a surgical procedure planned during the time the participant is expected to participate in the study * Transplanted organ (with exception of a corneal transplant greater than \[\>\] 12 weeks before the first administration of study intervention)

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Conditions

The condition(s) this trial relates to.

psoriasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Plaque psoriasis

Contacts and locations

Locations

  • AZ St. Lucas

    Ghent, 9000, Belgium

  • Aalborg Sygehus Syd

    Aalborg, 9100, Denmark

  • Aarhus University Hospital

    Aarhus, 8200, Denmark

  • Advanced Research Experts PLLC

    Nashville, Tennessee, 37211, United States

  • Allergo-Derm Bakos Kft.

    Szolnok, 5000, Hungary

  • Allgemeines Krankenhaus der Stadt Wien

    Vienna, 1090, Austria

  • Alliance Clinical Trials

    Waterloo, Ontario, N2J 1C4, Canada

  • Apex Dermatology Mayfield Heights

    Mayfield Heights, Ohio, 44124, United States

  • Arlington Research Center, Inc.

    Arlington, Texas, 76011, United States

  • Bacs-kiskun Megyei Korhaz

    Kecskemét, 6000, Hungary

  • Bioclinical Research Alliance Inc.

    Miami, Florida, 33155, United States

  • Bispebjerg Hospital

    København NV, 2400, Denmark

  • Buenos Aires Skin

    CABA, C1055AAO, Argentina

  • CCA Medical Research Corporation

    Ajax, Ontario, L1S7K8, Canada

  • CIPREC

    CABA, C1061AAS, Argentina

  • Cahaba Research Inc

    Birmingham, Alabama, 35244, United States

  • California Dermatology & Clinical Research Institute

    Encinitas, California, 92024, United States

  • Care Clinic Sp z o o

    Katowice, 40 568, Poland

  • Center for Clinical Studies

    Webster, Texas, 77598, United States

  • Center for Clinical Studies 1

    Houston, Texas, 77004, United States

  • Centre Hospitalier Universitaire de Liege Domaine Universitaire du Sart Tilman

    Liège, 4000, Belgium

  • Centrum Kliniczno Badawcze J Brzezicki B Gornikiewicz Brzezicka Lekarze Spolka Partnerska

    Elblag, 82 300, Poland

  • Centrum Medyczne Oporow

    Wroclaw, 52 416, Poland

  • Cleaver Dermatology

    Kirksville, Missouri, 63501, United States

  • Clinical Research Philadelphia

    Philadelphia, Pennsylvania, 19114, United States

  • Consultora Integral de Salud SRL

    Barrio Gral Paz Cba Capital, X5000, Argentina

  • Cornerstone Dermatology

    Coorparoo, 4151, Australia

  • Debreceni Egyetem Klinikai Kozpont

    Debrecen, 4032, Hungary

  • Derma-B Kft

    Debrecen, 4031, Hungary

  • Derma-Study-Center Friedrichshafen GmbH

    Friedrichshafen, 88045, Germany

  • Dermatologie Mahlow

    Mahlow, 15831, Germany

  • Dermatologie Maldegem

    Maldegem, 9990, Belgium

  • Dermatologist Medical Group of North County, Inc.

    Oceanside, California, 92056, United States

  • Dermatrials Research

    Hamilton, Ontario, L8N 1Y2, Canada

  • Dermed Centrum Medyczne Sp z o o

    Lodz, 90-265, Poland

  • Driven Research LLC

    Miami, Florida, 33126, United States

  • Dudley Group NHS Foundation Trust

    Dudley, DY1 2HQ, United Kingdom

  • Equity Medical

    Bowling Green, Kentucky, 42104, United States

  • Etyka Osrodek Badan Klinicznych

    Olsztyn, 10-117, Poland

  • Fachklinik Bad Bentheim

    Bad Bentheim, 48455, Germany

  • First OC Dermatology

    Fountain Valley, California, 92708, United States

  • Forcare Clinical Research Inc

    Tampa, Florida, 33613, United States

  • Frontier Derm Partners CRO, LLC

    Mill Creek, Washington, 98012, United States

  • Gemeinschaftspraxis Dres. Quist

    Mainz, 55128, Germany

  • Gentofte Hospital

    Hellerup, 2900, Denmark

  • Ghent University Hospital

    Ghent, 9000, Belgium

  • Grupo Dermatologico Y Estetico Pedro Jaen

    Madrid, 28002, Spain

  • Guys and St Thomas NHS Foundation Trust

    London, SE1 9RT, United Kingdom

  • Gyongyosi Bugat Pal Korhaz

    Gyöngyös, 3200, Hungary

  • Halitus Instituto Medico S.A. - Dermatologia y Estetica

    Caba, C1122AAF, Argentina

  • Hamilton Research LLC

    Alpharetta, Georgia, 30022, United States

  • Hamzavi Dermatology

    Fort Gratiot, Michigan, 48059, United States

  • Hautarztpraxis

    Witten, 58453, Germany

  • Health Concepts

    Rapid City, South Dakota, 57702, United States

  • Henry Ford Hospital

    Detroit, Michigan, 48202, United States

  • Hosp. Clinic de Barcelona

    Barcelona, 08036, Spain

  • Hosp. Clinico Univ. Lozano Blesa

    Zaragoza, 50009, Spain

  • Hosp. Clinico Univ. de Santiago

    Santiago Compostela, 15706, Spain

  • Hosp. Cuf Descobertas

    Lisbon, 1998 018, Portugal

  • Hosp. Gral. Univ. Dr. Balmis

    Alicante, 03010, Spain

  • Hosp. Ntra. Sra. de Valme

    Seville, 41014, Spain

  • Hosp. Univ. 12 de Octubre

    Madrid, 28041, Spain

  • Hosp. Univ. I Politecni La Fe

    Valencia, 46026, Spain

  • Hosp. Univ. Miguel Servet

    Zaragoza, 50009, Spain

  • Hosp. Univ. San Cecilio

    Granada, 18016, Spain

  • Hosp. Univ. de Cruces

    Barakaldo, 48902, Spain

  • Hosp. Univ. de La Princesa

    Madrid, 28006, Spain

  • Hosp. Virgen Macarena

    Seville, 41009, Spain

  • Hosp. de La Marina Baixa

    Villajoyosa, 03570, Spain

  • Hosp. de Manises

    Manises, 46940, Spain

  • Hospital Italiano de Buenos Aires

    CABA, C1199ABB, Argentina

  • ISA - Interdisciplinary Study Association GmbH

    Berlin, 10789, Germany

  • ISHI dermatology

    Mitcham, 3132, Australia

  • Indiana Clinical Trial Center

    Plainfield, Indiana, 46168, United States

  • Innovaderm Research Inc.

    Montreal, Quebec, H2X 2V1, Canada

  • Instituto De Especialidades De La Salud SRL

    Rosario, S2000DBS, Argentina

  • Instituto Medico De Alta Complejidad (IMAC)

    Buenos Aires, B1643CRO, Argentina

  • Instituto de Investigaciones Medicas Tucuman

    San Miguel de Tucumán, T4000, Argentina

  • Instituto de Neumonologia y Dermatologia

    Buenos Aires, C1425, Argentina

  • Integrative Skin Science and Research

    Sacramento, California, 95815, United States

  • Investigaciones Medicas IMOBA SRL

    CABA, C1056ABH, Argentina

  • Kalo Clinical Research

    West Valley City, Utah, 84120, United States

  • Kepler Universitatsklinikum GmbH

    Linz, 4020, Austria

  • Klinika Ambroziak Dermatologia

    Warsaw, 02 953, Poland

  • Klinikum Augsburg

    Augsburg, 86179, Germany

  • LKH Feldkirch

    Feldkirch, 6800, Austria

  • London North West University Healthcare NHS Trust

    Harrow, HA1 3UJ, United Kingdom

  • Lovegrove Dermatology

    London, Ontario, N6A 5R9, Canada

  • Lynderm Research Inc.

    Markham, Ontario, L3P 1X3, Canada

  • MR Medicina Reumatologica

    San Fernando, B1646, Argentina

  • Magdalena Opadczuk Carpe Diem Centrum Medycyny Estetycznej

    Warsaw, 02 661, Poland

  • Mautalen Salud e Investigacion

    CABA, C1128, Argentina

  • MedDerm Associates

    San Diego, California, 92103, United States

  • MediSearch Clinical Trials

    Saint Joseph, Missouri, 64506, United States

  • Medizinische Fakultaet Carl Gustav Carus Technische Universitaet Dresden

    Dresden, 01307, Germany

  • Medmare Egeszsegugyi Es Szolgaltato Bt.

    Veszprém, 8200, Hungary

  • Metro Boston Clinical Partners

    Brighton, Massachusetts, 02135, United States

  • Mid Yorkshire Hospital NHS Trust- Pinderfields Hospital

    Wakefield, WF1 4DG, United Kingdom

  • Mindout Research

    Buenos Aires, C1417EYG, Argentina

  • Minnesota Clinical Study Center

    New Brighton, Minnesota, 55112, United States

  • Modern Research Associates PLLC

    Dallas, Texas, 75231, United States

  • Monash Medical Centre

    Clayton, 3168, Australia

  • Mount Sinai Doctors Dermatology

    New York, New York, 10028, United States

  • NorCal Clinical Research

    Rocklin, California, 95765, United States

  • Northshore Medical Group

    Skokie, Illinois, 60076, United States

  • Obudai Egeszsegugyi Centrum Kft

    Budapest, 1036, Hungary

  • Odense University Hospital

    Odense, 5000, Denmark

  • Olive View-UCLA Education & Research Institute

    Sylmar, California, 91342, United States

  • Optima Research

    Boardman, Ohio, 44512, United States

  • Oregon Dermatology and Research Center

    Portland, Oregon, 97210, United States

  • Oregon Medical Research Center

    Portland, Oregon, 97201, United States

  • Osteo-Medic s.c A. Racewicz, J Supronik

    Bialystok, 15-351, Poland

  • Porcika Klinika - Vasarhelyi Sarkanyfu Kft.

    Hódmezővásárhely, 6800, Hungary

  • Premier Specialists

    Kogarah, 2217, Australia

  • Progressive Clinical Research

    San Antonio, Texas, 78213, United States

  • Renstar Medical Research

    Ocala, Florida, 34470, United States

  • Rosenpark Research GmbH

    Darmstadt, 64283, Germany

  • Royal Berkshire Hospital

    Reading, RG1 5AN, United Kingdom

  • Royal Melbourne Hospital

    Melbourne, 3050, Australia

  • SOLUMED Centrum Medyczne

    Poznan, 60 529, Poland

  • Sadick Research Group

    New York, New York, 10075, United States

  • Salford Royal Hospital

    Salford, M6 8HD, United Kingdom

  • SimcoDerm Medical and Surgical Dermatology Centre

    Barrie, Ontario, L4M 7G1, Canada

  • Sjællands University hospital

    Roskilde, 4000, Denmark

  • Skincare Studio Inc Dermatology Clinical Trials

    St. John's, Newfoundland and Labrador, A1E 1V4, Canada

  • Somerset Skin Centre

    Troy, Michigan, 48084, United States

  • Somogy Varmegyei Kaposi Mor Oktato Korhaz

    Kaposvár, 7400, Hungary

  • Southern California Dermatology

    Santa Ana, California, 92701, United States

  • Specderm Poznanska sp j

    Bialystok, 15 375, Poland

  • Specjalistyczny gabinet dermatologiczny Aplikacyjno Badawczy Marek Brzewski Pawel Brzewski Spolka Cywilna

    Krakow, 30 002, Poland

  • Studienzentrum Dr Schwarz Germany

    Langenau, 89129, Germany

  • Studienzentrum an der Hase GbR

    Bramsche, 49565, Germany

  • Synexus Magyarorszag Kft

    Gyula, 5700, Hungary

  • T Joseph Raoof Md Inc

    Encino, California, 91436, United States

  • Texas Dermatology and Laser Specialists

    San Antonio, Texas, 78218, United States

  • The Alfred Hospital

    Melbourne, 3004, Australia

  • The Centre de recherche Saint-Louis

    Québec, Quebec, G1W 4R4, Canada

  • The Derm Institute of West Michigan

    Caledonia, Michigan, 49316, United States

  • The Queen Elizabeth Hospital NHS Foundation Trust

    Kings Lynn, PE30 4ET, United Kingdom

  • Tufts Medical Center

    Boston, Massachusetts, 02111, United States

  • UPMC Department of Dermatology

    Pittsburgh, Pennsylvania, 15213, United States

  • UZ Brussel

    Brussels, 1090, Belgium

  • Uls Alto Ave - Hosp. Sra. Da Oliveira Guimaraes

    Guimarães, 4835 044, Portugal

  • Uls Sao Jose - Hosp. Sto Antonio Dos Capuchos

    Lisbon, 1169 050, Portugal

  • Ulssa Hosp. Santo Antonio

    Porto, 4099 001, Portugal

  • Unidade Local De Saude Da Regiao De Leiria Epe

    Leiria, 2410 197, Portugal

  • Universitaetsklinikum Muenster

    Münster, 48149, Germany

  • Universitaetsklinikum Schleswig Holstein Campus Kiel

    Kiel, 24105, Germany

  • Universitair Ziekenhuis Leuven

    Leuven, 3000, Belgium

  • Universitatsklinikum Bonn

    Bonn, 53127, Germany

  • University Hospital Southampton

    Southampton, So166yd, United Kingdom

  • University of Conn Health Center

    Farmington, Connecticut, 06030, United States

  • University of Iowa

    Iowa City, Iowa, 52242, United States

  • Universtitatsklinikum St Polten

    Sankt Pölten, 3100, Austria

  • Uno Medical Trials Ltd.

    Budapest, 1152, Hungary

  • Velocity Nova Sp z o o

    Skierniewice, 96 100, Poland

  • Veracity Clinical Research

    Woolloongabba, 4102, Australia

  • Westmead Hospital

    Westmead, 2145, Australia

  • Wilmington Dermatology Center

    Wilmington, North Carolina, 28405, United States

  • WroMedica I Bielicka A Strzalkowska s c

    Wroclaw, 51 685, Poland

More trials for these conditions

Other studies related to the condition(s) this trial covers.