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New pill could tame tough psoriasis

NCT ID NCT06220604

Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Sep 01, 2026 · Updated 4 times

Summary

This phase 3 study tests an experimental oral drug, JNJ-77242113, in about 731 adults with moderate to severe plaque psoriasis. Participants receive either the new drug, a placebo, or an active comparator (deucravacitinib) to see how well it clears skin lesions. The main goal is to measure improvement in psoriasis severity at 16 weeks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
JNJ-77242113 (an oral drug for psoriasis)
What this could lead to
If successful, this could offer a new oral treatment option for people with moderate to severe plaque psoriasis.
What could go wrong
This is a phase 3 trial, but results are not yet published. The drug may not prove more effective than existing treatments, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

731 people

The number who actually took part.

Started

Mar 2024

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of plaque psoriasis, with or without psoriatic arthritis (PsA), for at least 26 weeks prior to the first administration of study intervention * Total body surface area (BSA) greater than or equal to (\>=)10 percent (%) at screening and baseline * Total psoriasis area and severity index (PASI) \>=12 at screening and baseline * Total investigator global assessment (IGA) \>=3 at screening and baseline * Candidate for phototherapy or systemic treatment for plaque psoriasis Exclusion Criteria: * Nonplaque form of psoriasis (for example, erythrodermic, guttate, or pustular) * Current drug-induced psoriasis (for example, a new onset of psoriasis or an exacerbation of psoriasis from beta blockers, calcium channel blockers, or lithium) * A current diagnosis or signs or symptoms of severe, progressive, or uncontrolled renal, liver, cardiac, vascular, pulmonary, gastrointestinal, endocrine, neurologic, hematologic, rheumatologic, psychiatric, or metabolic disturbances * Known allergies, hypersensitivity, or intolerance to JNJ-77242113, deucravacitinib or to any of the excipients or components of the study intervention * Major surgical procedure, (for example, requiring general anesthesia) within 8 weeks before screening, or will not have fully recovered from surgical procedure, or has a surgical procedure planned during the time the participant is expected to participate in the study

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Conditions

The condition(s) this trial relates to.

psoriasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Plaque psoriasis

Contacts and locations

Locations

  • ActivMed Practices and Research

    Methuen, Massachusetts, 01844, United States

  • Alliance Dermatology and MOHS Center P C

    Phoenix, Arizona, 85032, United States

  • Arlington Dermatology

    Rolling Meadows, Illinois, 60008, United States

  • Arlington Research Center, Inc.

    Arlington, Texas, 76011, United States

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Bacs Kiskun Varmegyei Oktatokorhaz

    Kecskemét, 6000, Hungary

  • Bexley dermatology research

    Bexley, Ohio, 43209, United States

  • Bioclinical Research Alliance Inc.

    Miami, Florida, 33155, United States

  • Bugat Pal Korhaz

    Gyöngyös, 3200, Hungary

  • CHA Bundang Medical Center, CHA University

    Seongnam, 13496, South Korea

  • CRS Clinical Research Services Berlin GmbH

    Berlin, 13627, Germany

  • Cabinet Medical Dermato-Venerologie

    Cluj-Napoca, 400105, Romania

  • California Dermatology & Clinical Research Institute

    Encinitas, California, 92024, United States

  • Care Clinic

    Katowice, 40 568, Poland

  • Carpe Diem Centrum Medycyny Estetycznej

    Warsaw, 02 661, Poland

  • Center for Clinical Studies

    Webster, Texas, 77598, United States

  • Centre De Recherche Dermatologique Du Quebec Metropolitain

    Québec, Quebec, G1V 4X7, Canada

  • CentroDerm GmbH

    Wuppertal, 42287, Germany

  • Centrul Medical Vitaplus

    Craiova, 200541, Romania

  • Centrum Medyczne Angelius Provita

    Katowice, 40 611, Poland

  • Cepes - Fmabc

    São Paulo, 09060-870, Brazil

  • Chosun university hospital

    Gwangju, 61453, South Korea

  • Chronos Clinica Medica Ltda

    Brasília, 72145-450, Brazil

  • Chung Shan Medical University Hospital

    Taichung, 40201, Taiwan

  • Cleaver Dermatology

    Kirksville, Missouri, 63501, United States

  • Clinica Gaias

    Santiago de Compostela, 15702, Spain

  • Clinical Research Center of the Carolinas LLC

    Charleston, South Carolina, 29407, United States

  • Cope Family Medicine - Ogden Clinic

    Bountiful, Utah, 84010, United States

  • DermAssociates, PC

    Rockville, Maryland, 20850, United States

  • DermEdge Research

    Mississauga, Ontario, L4Y 4C5, Canada

  • Derma-Study-Center Friedrichshafen GmbH

    Friedrichshafen, 88045, Germany

  • Dermatologist Medical Group of North County, Inc.

    Oceanside, California, 92056, United States

  • Dermatology Clinical Research Center of San Antonio

    San Antonio, Texas, 78229, United States

  • Diamond Clinic

    Krakow, 31 559, Poland

  • Dr. Chih ho Hong Medical

    Surrey, British Columbia, V3R 6A7, Canada

  • Essential Medical Research

    Tulsa, Oklahoma, 74137, United States

  • Etyka Osrodek Badan Klinicznych

    Olsztyn, 10-117, Poland

  • Eurofins bioskin GmbH

    Hamburg, 20095, Germany

  • Fachklinik Bad Bentheim

    Bad Bentheim, 48455, Germany

  • Forcare Clinical Research Inc

    Tampa, Florida, 33613, United States

  • Funfarme Sjrp

    São José do Rio Preto, 15090-000, Brazil

  • Great Lakes Research Group

    Bay City, Michigan, 48706, United States

  • Hallym University Sacred Heart Hospital

    Anyang-si, 14068, South Korea

  • Hamzavi Dermatology

    Canton, Michigan, 48187, United States

  • Hautarztpraxis

    Mahlow, 15831, Germany

  • Hautarztpraxis 1

    Witten, 58453, Germany

  • Hautarztpraxis Dr. Mihaescu

    Augsburg, 86150, Germany

  • Hautmedizin Saar Science Hms GmbH

    Merzig, 66663, Germany

  • Hautzentrum Dulmen

    Dülmen, 48249, Germany

  • Hosp Clinic de Barcelona

    Barcelona, 08036, Spain

  • Hosp Clinico Univ de Salamanca

    Salamanca, 37007, Spain

  • Hosp. Clinico Univ. Lozano Blesa

    Zaragoza, 50009, Spain

  • Hosp. Clinico Univ. de Santiago

    Santiago de Compostela, 15706, Spain

  • Hosp. Ntra. Sra. de Valme

    Seville, 41014, Spain

  • Hosp. Univ. Fundacion Alcorcon

    Alcorcón, 28922, Spain

  • Hosp. Univ. Germans Trias I Pujol

    Badalona, 08916, Spain

  • Hosp. Virgen Macarena

    Seville, 41009, Spain

  • Hosp. de La Marina Baixa

    Villajoyosa, 03570, Spain

  • Hosp. de Manises

    Manises, 46940, Spain

  • Hospital Das Clinicas Da Faculdade De Medicina Da USP

    São Paulo, 05403 900, Brazil

  • Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto

    Ribeirão Preto, 14051140, Brazil

  • ISHI dermatology

    Mitcham, 3132, Australia

  • Innovaderm Research Inc.

    Montreal, Quebec, H2X 2V1, Canada

  • Jagiellonskie Centrum Innowacji

    Krakow, 30-348, Poland

  • Kalo Clinical Research

    West Valley City, Utah, 84120, United States

  • Kaohsiung Medical University Chung Ho Memorial Hospital

    Kaohsiung City, 80756, Taiwan

  • Kaohsiung Veterans General Hospital

    Kaohsiung City, 81362, Taiwan

  • Klinikum Darmstadt GmbH - Hautklinik

    Darmstadt, 64283, Germany

  • Klinikum Oldenburg

    Oldenburg, 26133, Germany

  • Korea University Ansan Hospital

    Ansan-si, 15355, South Korea

  • Korea University Guro Hospital

    Seoul, 8308, South Korea

  • Krakowskie Centrum Badan Klinicznych

    Krakow, 30-303, Poland

  • Lovegrove Dermatology

    London, Ontario, N6A 5R9, Canada

  • Lynderm Research Inc.

    Markham, Ontario, L3P 1X2, Canada

  • Medizinische Fakultaet Carl Gustav Carus Technische Universitaet Dresden

    Dresden, 01307, Germany

  • Metro Boston Clinical Partners

    Brighton, Massachusetts, 02135, United States

  • Miami Dermatology And Laser Institute

    Miami, Florida, 33133, United States

  • Monash Medical Centre

    Clayton, 3168, Australia

  • National Cheng Kung University Hospital

    Tainan, 710, Taiwan

  • New Derm Clinic

    Timișoara, 300757, Romania

  • Niesmann & Othlinghaus GbR

    Bochum, 44793, Germany

  • North York Research Inc

    Toronto, Ontario, M2N 3A6, Canada

  • Oregon Dermatology & Research Center

    Portland, Oregon, 97210-2996, United States

  • Paddington Testing Co, Inc.

    Philadelphia, Pennsylvania, 19103, United States

  • Palmetto Clinical Trial Services, LLC

    Greenville, South Carolina, 29615, United States

  • Premier Specialists

    Kogarah, 2217, Australia

  • Privatpraxis Dr. Hilton & Partner

    Düsseldorf, 40212, Germany

  • Prywatny Gabinet Dermatologiczny Elzbieta Klujszo

    Kielce, 25-316, Poland

  • Qualmedica Research

    Owensboro, Kentucky, 42301, United States

  • Renew Clinic

    Bialystok, 15 797, Poland

  • Royal Melbourne Hospital

    Parkville, 3050, Australia

  • Royalderm Agnieszka Nawrocka

    Warsaw, 02-962, Poland

  • SGD s.c.

    Krakow, 30-002, Poland

  • Sc Iasiprest Srl

    Iași, 700381, Romania

  • Skin Centre for Dermatology

    Peterborough, Ontario, K9J 5K2, Canada

  • Skin Sciences, PLLC

    Louisville, Kentucky, 40217, United States

  • Somerset Skin Centre

    Troy, Michigan, 48084, United States

  • Southeast Dermatology Specialists

    Douglasville, Georgia, 30135, United States

  • Spitalul Clinic Judetean Mures

    Târgu Mureş, 540342, Romania

  • Spitalul Clinic Judetean de Urgenta

    Craiova, 200642, Romania

  • Spitalul Clinic Judetean de Urgenta Bihor

    Oradea, 410167, Romania

  • Springville Dermatology CCT Research

    Springville, Utah, 84663, United States

  • Synexus Magyarorszag Kft

    Gyula, 5700, Hungary

  • Synexus Magyarorszag Kft 1

    Zalaegerszeg, H-8900, Hungary

  • Synexus Polska Sp z o o Oddzial w Warszawie

    Warsaw, 02 672, Poland

  • T Joseph Raoof Md Inc

    Encino, California, 91436, United States

  • Taichung Veterans General Hospital

    Taichung, 40705, Taiwan

  • Taipei Medical University

    Taipei, 110, Taiwan

  • Taipei Municipal Wanfang Hospital

    Taipei, 116, Taiwan

  • The Alfred Hospital

    Melbourne, 3004, Australia

  • The Catholic University of Korea Bucheon St Mary s Hospital

    Bucheon-si, 14647, South Korea

  • The Derm Institute of West Michigan

    Caledonia, Michigan, 49316, United States

  • The Skin Centre

    Benowa, 4217, Australia

  • Toronto Research Centre

    Toronto, Ontario, M3H 5Y8, Canada

  • UCSF Fresno

    Fresno, California, 93701, United States

  • UNESP - Faculdade de Medicina da Universidade Estadual Paulista - Campus Botucatu

    Botucatu, 18618-686, Brazil

  • UT Southwestern Medical Center

    Dallas, Texas, 75390, United States

  • Universitaetsklinikum Heidelberg

    Heidelberg, 69120, Germany

  • Universitaetsklinikum Muenster

    Münster, 48149, Germany

  • Universitatsmedizin der Johannes Gutenberg Universitat Mainz

    Mainz, 55131, Germany

  • University of California Los Angeles - Division of Dermatology

    Los Angeles, California, 90024, United States

  • University of Michigan

    Ann Arbor, Michigan, 48109, United States

  • Uno Medical Trials Ltd.

    Budapest, 1152, Hungary

  • Virginia Dermatology Skin Cancer Center Pllc

    Norfolk, Virginia, 23502, United States

  • Wallace Medical Group, Inc

    Los Angeles, California, 90056, United States

  • Wiseman Dermatology Research Inc.

    Winnipeg, Manitoba, R3M 3Z4, Canada

  • WroMedica I Bielicka A Strzalkowska s c

    Wroclaw, 51 685, Poland

  • XLR8 Medical Research

    Windsor, Ontario, N8T 1E6, Canada

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