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New pill could help psoriasis on scalp, genitals, and palms

NCT ID NCT06095102

Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 28, 2026 · Updated 3 times

Summary

This phase 3 study tests an oral drug called JNJ-77242113 in 311 adults with plaque psoriasis affecting special areas like the scalp, genitals, or palms and soles. Participants receive either the drug or a placebo for 16 weeks. The main goal is to see if the drug clears or nearly clears the skin in these sensitive spots. It is not a cure, but if successful, it could provide a new treatment option for people with stubborn psoriasis in these areas.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
JNJ-77242113 (oral drug)
What this could lead to
If it works, this could offer a new oral treatment option for people with plaque psoriasis in hard-to-treat areas like the scalp, genitals, and palms/soles.
What could go wrong
This is a phase 3 trial, but results are not yet published. The drug may not work better than placebo, and side effects are possible. It is not a cure—psoriasis may return after stopping treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

311 people

The number who actually took part.

Started

Oct 2023

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

12 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of plaque psoriasis, with or without psoriatic arthritis (PsA), for at least 26 weeks prior to the first administration of study intervention * Candidate for phototherapy or systemic treatment for plaque psoriasis * Need to meet criteria: Total body surface area (BSA) greater than or equal to (\>=)1 percent (%) at screening and baseline, and investigator global assessment (IGA) (overall) \>=2 at screening and baseline and at least one of the following: scalp-specific investigator global assessment (ss-IGA) score \>=3 at screening and baseline, and/or static physician's global assessment of genitalia (sPGA-G) \>=3 at screening and baseline, and/or physician's global assessment of hands and feet (hf-PGA) score \>=3 at screening and baseline * Failed to respond to at least 1 topical therapy (example, corticosteroids, calcineurin inhibitors, and/or vitamin D analogs) used for treatment of psoriasis * Confirmation of plaque psoriasis in a non-special area (example, areas excluding scalp, genital, palmoplantar) at screening and baseline Exclusion Criteria: * Nonplaque form of psoriasis (example, erythrodermic, guttate, or pustular) * Dermatoses other than plaque psoriasis (such as contact dermatitis) or palmoplantar pustulosis of the palmoplantar area (if hf-PGA \>=3 at baseline) * Current drug-induced psoriasis (example, a new onset of psoriasis or an exacerbation of psoriasis from beta blockers, calcium channel blockers, or lithium) * A current diagnosis or signs or symptoms of severe, progressive, or uncontrolled renal, liver, cardiac, vascular, pulmonary, gastrointestinal, endocrine, neurologic, hematologic, rheumatologic, psychiatric, or metabolic disturbances * Known allergies, hypersensitivity, or intolerance to JNJ-77242113 or its excipients

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Conditions

The condition(s) this trial relates to.

psoriasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Plaque psoriasis

Contacts and locations

Locations

  • Alberta DermaSurgery Centre

    Edmonton, Alberta, T6G 1C3, Canada

  • Allcutis Research 1

    Beverly, Massachusetts, 01915, United States

  • Allergo-Derm Bakos Kft.

    Szolnok, 5000, Hungary

  • Arlington Dermatology

    Rolling Meadows, Illinois, 60008, United States

  • Arlington Research Center, Inc.

    Arlington, Texas, 76011, United States

  • Austin Institute for Clinical Research

    Pflugerville, Texas, 78660, United States

  • CEDIC Centro de Investigacion clinica

    Caba, C1060ABN, Argentina

  • CIPREC

    Buenos Aires, C1061AAS, Argentina

  • CRS Clinical Research Services Berlin GmbH

    Berlin, 13627, Germany

  • California Dermatology & Clinical Research Institute

    Encinitas, California, 92024, United States

  • Center for Clinical Studies

    Webster, Texas, 77598, United States

  • Center for Clinical Studies 1

    Houston, Texas, 77004, United States

  • Center for Dermatology and Plastic Surgery

    Scottsdale, Arizona, 85260, United States

  • Centre Dermatologique

    Québec, Quebec, G1V 4X7, Canada

  • Centro Privado de Medicina Familiar

    Buenos Aires, C1417EYG, Argentina

  • Centrum Medyczne Oporow

    Wroclaw, 52 416, Poland

  • Centrum Medyczne Promed

    Krakow, 31-411, Poland

  • Centrum Medyczne dr Rajzer Sp z o o

    Krakow, 30 438, Poland

  • Clinical Research Center sp z o o MEDIC R s k

    Poznan, 61 731, Poland

  • Conexa Investigacion Clinica S.A.

    CABA, C1012AAY, Argentina

  • Cope Family Medicine - Ogden Clinic

    Bountiful, Utah, 84010, United States

  • Dawes Fretzin Clinical Research Group LLC

    Indianapolis, Indiana, 46250, United States

  • Derma-B Kft

    Debrecen, 4031, Hungary

  • Dermatologikum Hamburg Gmbh

    Hamburg, 20354, Germany

  • Dermatology Clinical Research Center of San Antonio

    San Antonio, Texas, 78229, United States

  • Dermatology and Advanced Aesthetics

    Lake Charles, Louisiana, 70605, United States

  • Dermed Centrum Medyczne Sp z o o

    Lodz, 90-265, Poland

  • Dermodent Centrum Medyczne Aldona Czajkowska Rafal Czajkowski S C

    Osielsko, 86031, Poland

  • Dorota Bystrzanowska High-Med. Przychodnia Specjalistyczna

    Warsaw, 01 817, Poland

  • Dundee Dermatology

    West Dundee, Illinois, 60118, United States

  • Forcare Clinical Research Inc

    Tampa, Florida, 33613, United States

  • Frontier Derm Partners CRO, LLC

    Mill Creek, Washington, 98012, United States

  • Hamilton Research LLC

    Alpharetta, Georgia, 30022, United States

  • Hamzavi Dermatology

    Fort Gratiot, Michigan, 48059, United States

  • Hautarztpraxis 2

    Witten, 58453, Germany

  • Hosp. Del Mar

    Barcelona, 08003, Spain

  • Hosp. Sant Joan de Deu

    Esplugues de Llobregat, 08950, Spain

  • Hosp. Univ. 12 de Octubre

    Madrid, 28041, Spain

  • Hosp. Univ. Germans Trias I Pujol

    Badalona, 08916, Spain

  • Hosp. Univ. I Politecni La Fe

    Valencia, 46026, Spain

  • Hosp. Univ. San Cecilio

    Granada, 18016, Spain

  • Hosp. Virgen Macarena

    Seville, 41009, Spain

  • Hosp. de Manises

    Manises, 46940, Spain

  • ISA - Interdisciplinary Study Association GmbH

    Berlin, 10789, Germany

  • Indiana Clinical Trial Center

    Plainfield, Indiana, 46168, United States

  • Innovaderm Research Inc.

    Montreal, Quebec, H2X 2V1, Canada

  • Johnson Dermatology

    Fort Smith, Arkansas, 72916, United States

  • Kaohsiung Chang Gung Memorial Hospital

    Kaohsiung City, 83301, Taiwan

  • Karadeniz Teknik University Medical Faculty

    Trabzon, 61080, Turkey (Türkiye)

  • Klinika Ambroziak Dermatologia

    Warsaw, 02 953, Poland

  • Klinische Forschung Schwerin GmbH

    Schwerin, 19055, Germany

  • Konkuk University Medical Center

    Seoul, 05030, South Korea

  • Korea University Guro Hospital

    Seoul, 08308, South Korea

  • Linkou Chang Gung Memorial Hospital

    Taoyuan, 33382, Taiwan

  • London North West University Healthcare NHS Trust

    Harrow, HA1 3UJ, United Kingdom

  • Lynderm Research Inc.

    Markham, Ontario, L3P 1X3, Canada

  • MediSearch Clinical Trials

    Saint Joseph, Missouri, 64506, United States

  • Medizinische Fakultaet Carl Gustav Carus Technische Universitaet Dresden

    Dresden, 01307, Germany

  • Medmare Egeszsegugyi Es Szolgaltato Bt.

    Veszprém, 8200, Hungary

  • Minnesota Clinical Study Center

    New Brighton, Minnesota, 55112, United States

  • National Taiwan University Hospital

    Taipei, 10048, Taiwan

  • National Taiwan University Hospital Hsin Chu Branch

    Hsinchu, 30059, Taiwan

  • Necmettin Erbakan University Meram Medical Faculty

    Konya, 42080, Turkey (Türkiye)

  • Niesmann & Othlinghaus GbR

    Bochum, 44793, Germany

  • Obudai Egeszsegugyi Centrum Kft

    Budapest, 1036, Hungary

  • Ondokuz Mayis University

    Samsun, 55270, Turkey (Türkiye)

  • Optima Research

    Boardman, Ohio, 44512, United States

  • Oregon Dermatology and Research Center

    Portland, Oregon, 97210, United States

  • Osteo-Medic s.c A. Racewicz, J Supronik

    Bialystok, 15-351, Poland

  • Paddington Testing Co, Inc.

    Philadelphia, Pennsylvania, 19103, United States

  • Pecsi Tudomanyegyetem

    Borgyogyaszati Klinika, 7632, Hungary

  • Progressive Clinical Research

    San Antonio, Texas, 78213, United States

  • Pusan National University Hospital

    Busan, 49241, South Korea

  • Rosenpark Research GmbH

    Darmstadt, 64283, Germany

  • SOLUMED Centrum Medyczne

    Poznan, 60 529, Poland

  • SZTE AOK Szent-Gyorgyi Albert Klinikai Kozpont, Borgyogyaszati és Allergologiai Klinika

    Szeged, 6720, Hungary

  • Salford Royal Hospital

    Salford, M6 8HD, United Kingdom

  • Schweiger Dermatology Group

    East Windsor, New Jersey, 08520, United States

  • Seoul National University Bundang Hospital

    Seongnam-si, 13620, South Korea

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Skin Centre for Dermatology

    Peterborough, Ontario, K9J 5K2, Canada

  • Skin Specialists

    Omaha, Nebraska, 68144, United States

  • Skinsense Medical Research

    Saskatoon, Saskatchewan, S7K 2C1, Canada

  • Specderm Poznanska sp j

    Bialystok, 15-375, Poland

  • Specjalistyczny gabinet dermatologiczny Aplikacyjno Badawczy Marek Brzewski Pawel Brzewski Spolka Cywilna

    Krakow, 30-002, Poland

  • Universitaetsklinikum Frankfurt

    Frankfurt am Main, 60590, Germany

  • University Hospital Southampton NHS Foundation Trust

    Southampton, SO16 6YD, United Kingdom

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, 15213, United States

  • Wro Medica

    Wroclaw, 51 685, Poland

  • York Dermatology Clinic and Research Centre

    Richmond Hill, Ontario, L4B1L1, Canada

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