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New hope for kidney disease: JADE101 trial launches

NCT ID NCT07541287

Disease control Sponsor: Jade Biosciences, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 21, 2026 · Updated 4 times

Summary

This study tests a new drug, JADE101, in 30 adults with IgA nephropathy, a kidney disease. The goal is to see if the drug is safe and can reduce protein in the urine, a sign of kidney damage. Participants must be on stable standard care and have a kidney biopsy confirming the disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

Apr 2029

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Male or female participants 18-60 years of age, inclusive, and of local legal consenting age at the time of signing the informed consent 2. eGFR ≥ 30 mL/min/1.73 m2 3. Biopsy-confirmed primary IgAN 4. Receiving stable and maximally tolerated doses of either ACEi or ARB as per standard of care (SoC) and applicable guidelines for at least 12 weeks prior to the initial screening visit, with no intention to alter the dose or discontinue treatment, unless medically necessary 5. UPCR ≥ 0.75 g/g 6. Willing to provide written informed consent 7. Willing and able to comply with scheduled study visits, treatment plans, laboratory tests, and other study procedures 8. Willing and able to comply with contraceptive and lifestyle requirements Exclusion Criteria: 1. Secondary forms of IgAN 2. Known or suspected coexisting Chronic Kidney Disease (CKD) other than IgAN 3. Known or suspected rapidly progressive glomerulonephritis (RPGN) 4. Evidence of pathological findings in the kidney biopsy in addition to IgAN (eg, minimal change disease, diabetic kidney disease, membranous nephropathy, focal segmental glomerulosclerosis, or lupus nephritis); hypertensive vascular changes are acceptable 5. Known or suspected primary or secondary immunodeficiency disorder 6. Evidence of tuberculosis infection at screening 7. Any chronic infectious disease 8. Any acute infectious disease at time of screening 9. Received bone marrow, hematologic stem cell transplantation, or a solid organ transplant, including kidney 10. Known or suspected alcohol or drug abuse 11. Any clinically significant and/or unstable or uncontrolled medical condition as assessed by the investigator 12. Malignancy within the past 5 years; nonmelanoma skin cancer and curatively treated cervical carcinoma in situ are allowed Other protocol-defined inclusion/exclusion criteria may apply

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Conditions

The condition(s) this trial relates to.

autoimmune disease glomerulonephritis IgA glomerulonephritis immune system disorder kidney disorder nephritis proteinuria urinary system disorder Urogenital Diseases

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IgA nephropathy

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    15 sites in 5 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Jade Clinical Site

    RECRUITING

    Chula Vista, California, 91910, United States

  • Jade Clinical Site

    RECRUITING

    Arvada, Colorado, 80002, United States

  • Jade Clinical Site

    RECRUITING

    Denver, Colorado, 80220, United States

  • Jade Clinical Site

    RECRUITING

    Orlando, Florida, 32806, United States

  • Jade Clinical Site

    RECRUITING

    Pembroke Pines, Florida, 33029, United States

  • Jade Clinical Site

    RECRUITING

    Houston, Texas, 77099, United States

  • Jade Clinical Site

    RECRUITING

    Concord, New South Wales, 2138, Australia

  • Jade Clinical Site

    RECRUITING

    Christchurch, 8011, New Zealand

  • Jade Clinical Site

    RECRUITING

    Anyang-si, 14068, South Korea

  • Jade Clinical Site

    RECRUITING

    Seongnam-si, 13620, South Korea

  • Jade Clinical Site

    RECRUITING

    Seoul, 03080, South Korea

  • Jade Clinical Site

    RECRUITING

    Seoul, 03722, South Korea

  • Jade Clinical Site

    RECRUITING

    Seoul, 06351, South Korea

  • Jade Clinical Site

    RECRUITING

    Suwon, 16499, South Korea

  • Jade Clinical Site

    RECRUITING

    Taipei, 100225, Taiwan

More trials for these conditions

Other studies related to the condition(s) this trial covers.