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IVF study reveals: Mom's stress shapes Baby's brain, not just genes

NCT ID NCT07296107

Knowledge-focused Sponsor: Columbia University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 08, 2026 · Updated 2 times

Summary

This study looks at how a mother's stress during pregnancy might affect her baby's brain and behavior. By comparing IVF pregnancies where the baby is genetically related to the mother versus those where the baby is not (using donor eggs), researchers can tell if stress effects are due to the prenatal environment or shared genes. About 360 women will answer questionnaires, give blood samples, and allow monitoring of the baby's heart rate and brain activity.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 360 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

Jul 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This five-year study will recruit and enroll approximately 200 pregnant individuals, ages 18-50 years, using IVF (120 homologous, 60 donor oocyte/embryo) and their offspring to achieve a post-attrition sample size of n=180. While based in Washington Heights, the sample reflects individuals undergoing IVF, not the general neighborhood. Based on Columbia Fertility Center data and national IVF trends, the investigators expect participants to be mostly Non-Hispanic/Latinx. While the investigators aim for inclusivity and diversity, non-English speakers will not be enrolled due to study team language constraints.

Ages

18 to 50 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Individuals at 18-28 gestational weeks with donor and homologous IVF pregnancies, ages 18-50. 2. Participants must be patients receiving their perinatal health care through Columbia University Irving Medical Center's Department of OB/GYN and delivering at New York-Presbyterian Morgan Stanley Children's Hospital. 3. Participants must be patients delivering at Columbia University Irving Medical Center's Department of OB/GYN and delivering at New York-Presbyterian Morgan Stanley Children's Hospital. 4. Participants will include the offspring of patients receiving care and delivering at the above institutions. 5. Enrollment Location(s): Columbia University Irving Medical Center's Department of OB/GYN, delivering at New York-Presbyterian Morgan Stanley Children's Hospital. Exclusion Criteria: 1. Identified addiction disorder 2. Severe psychiatric condition (defined as symptoms that significantly impair daily functioning and are untreated or not effectively managed) 3. Multiple fetal pregnancy 4. Known chromosomal, genetic, or major fetal malformations (unlikely due to routine preimplantation genetic testing) 5. Inflammatory conditions including rheumatoid arthritis, lupus, and multiple sclerosis 6. Not planning to deliver at a CUIMC-affiliated hospital

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Conditions

The condition(s) this trial relates to.

Developmental Origins of Health and Disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Child development Maternal distress

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Columbia University Irving Medical Center/New York Presbyterian Hospital

    RECRUITING

    New York, New York, 10032, United States

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