Eye surgeons hunt for the perfect hole size to prevent Post-Transplant problems
NCT ID NCT07577635
First seen Jun 24, 2026 · Last updated Jul 02, 2026 · Updated 2 times
Summary
This study follows 100 adults getting DMEK surgery, a type of corneal transplant. Before surgery, patients get a small laser or surgical hole in the iris to prevent pressure buildup. Researchers will measure the hole size with a special camera and track whether patients develop high eye pressure or see glare or halos. The goal is to find the hole size that best avoids these complications.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could help eye surgeons choose the best iridotomy size to reduce complications after DMEK surgery.
- What could go wrong
- This is an observational study, not a treatment trial, so it won't directly test a new therapy. Results may not lead to immediate changes in practice.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jun 2026
An estimate. Start dates often move.
- Expected to finish
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Jul 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adult patients undergoing Descemet membrane endothelial keratoplasty (DMEK) for corneal endothelial disease at the Department of Ophthalmology, University Hospital Leipzig, in whom a preoperative laser iridotomy or intraoperative surgical iridectomy is performed as part of standard care.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults aged ≥ 18 years * Patients undergoing Descemet membrane endothelial keratoplasty (DMEK) at the Department of Ophthalmology, University Hospital Leipzig * Preoperative Nd:YAG laser iridotomy or intraoperative surgical iridectomy performed as part of standard care * Ability to provide written informed consent * Willingness to complete the postoperative dysphotopsia questionnaire Exclusion Criteria: * Inability to provide informed consent or refusal to participate * Pre-existing surgical iridectomy * Missing or incomplete preoperative or postoperative anterior segment OCT data * Active anterior uveitis or panuveitis at the time of surgery
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
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