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ICU feeding showdown: continuous vs intermittent – which is better for recovery?

NCT ID NCT07173504

Knowledge-focused Sponsor: Gelderse Vallei Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether giving tube feeding in four daytime portions (intermittent) is better than the standard 24-hour continuous drip for critically ill patients in the ICU. Researchers will track blood sugar control, gut function, sleep quality, and muscle loss in 124 adults over up to 5 days. The goal is to find a feeding pattern that improves metabolic health without harming recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
intermittent enteral nutrition (tube feeding given in four 1-hour daytime portions)
What this could lead to
If it works, this could point toward a better feeding schedule for ICU patients, potentially improving blood sugar control and recovery.
What could go wrong
This is a small, early-stage study (124 people) looking at short-term effects over only 5 days. Results may not apply to all ICU patients or lead to clear changes in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 124 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Sep 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥18 years; 2. Receiving or eligible to receive exclusively gastric tube feeding; 3. Expected ICU stay ≥48 hours; 4. Receiving or anticipated to receive invasive mechanical ventilation within 48 hours after ICU admission. Exclusion Criteria: 1. The treating clinician considers participation in the study clinically contraindicated (e.g., change in feeding regimen, no possibility for placement of CGM on arms, not able to receive exclusive gastric tube feeding); 2. Death is deemed to be imminent or inevitable during admission, and the attending doctor, patient, or substitute decision-maker is not committed to active treatment; 3. Pregnancy; 4. Expected fasting for ≥12 hours during the study period, for example, due to medical procedures; 5. Readmission in last 14 days; 6. Patients with burn injuries; 7. Participating in another nutritional intervention study.

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Conditions

The condition(s) this trial relates to.

Critical Illness

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Critical illness

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    5 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Deventer Ziekenhuis

    RECRUITING

    Deventer, Overijssel, 7416 SE, Netherlands

  • Gelderse Vallei Hospital

    RECRUITING

    Ede, Gelderland, 6716 RP, Netherlands

  • Haga Ziekenhuis

    RECRUITING

    The Hague, South Holland, 2545 AA, Netherlands

  • Martini Ziekenhuis

    RECRUITING

    Groningen, Provincie Groningen, 9728NT, Netherlands

  • Medisch Spectrum Twente

    RECRUITING

    Enschede, Overijssel, 7512KZ, Netherlands

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