Intermittent fasting may beat daily dieting for belly fat loss

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 35-69 years old * BMI between 25-40 kg/m2 * Currently non-smoking * No serious health issues * Fully vaccinated for COVID-19 * Normal blood chemistry profile * East Asian (Chinese, Japanese, Korean), Filipino, Native Hawaiian/other Pacific Islander or white/European ancestry * Non-drinkers / low habitual drinkers, i.e., men ≤15 drinks per week, women ≤10 drinks per week * Volunteers living on the island of Oahu * For peri-menopausal women, the investigators will require that they had their last period at least 1 year before baseline) * DXA VAT ≥90 cm2 for men and ≥80 cm2 for women * Able to read, speak, and write in English Exclusion Criteria: * Pregnancy * Contraindication to MR imaging (e.g. pacemaker, claustrophobia, metal implants) * Previous surgery to remove any part of the small intestine, colon or rectum (e.g. ileostomy or colectomy) or an amputation of a leg or arm. * For women, taking any anti-estrogen medications (e.g tamoxifen, Nolvadex, Istubal, Valodex) * For men, taking any anti-androgen medications (e.g., Eulexin (flutamide); Anandron or Nilandron (nilutamide); Casodex (bicalutamide); Proscar or Propecia (finasteride); Avodart (dutasteride); or bexlosteride, izonsteride, turosteride, episteride). * Diagnosis of Type 1 diabetes or Type 2 diabetes and taking insulin for treatment * Diagnosis of thyroid conditions under treatment with hormones or medications. * Serious health issues such as dialysis, organ transplant, celiac disease, Crohn's disease, chronic liver disease, active case of hepatitis B or C, chronic kidney disease, or any condition that, in the opinion of the investigator, is a contraindication to participation. * Previous problem with fasting blood collection * Cannot exercise (walk) for up to 1hr/day Deferral Criteria : Volunteers with the following conditions will be called back after the specified duration: * Treatments in past 6 months: chemotherapy or radiation of abdomen/pelvis; corticosteroid hormones; prescription weight loss drugs; estrogen/androgen receptor blockers * Substantial weight change (\>20lbs) in past 6 months * Antibiotic use in past 3 months * Colonoscopy, sigmoidoscopy, colon irrigation/bowel cleaning in the past 3 months * MRI/CAT scan with contrast in the past 2 weeks