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Shock therapy for knees? electrical zaps may boost exercise benefits

NCT ID NCT06744036

Symptom relief Sponsor: University of Nove de Julho Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding a mild electrical current (interferential current) to a standard exercise program can further reduce pain and improve function in people with knee osteoarthritis. 138 adults aged 40-75 with knee pain will be split into three groups: exercise only, exercise plus real electrical stimulation, or exercise plus a placebo device. The treatment lasts 8 weeks, and participants are followed for another 4 weeks to see if any benefits last.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
interferential current (a type of electrical stimulation)
What this could lead to
If it works, this could provide a simple, drug-free way to boost the pain-relieving and function-improving effects of exercise for people with knee osteoarthritis.
What could go wrong
This is a small, early-stage trial. The added benefit of interferential current may be small or no better than placebo. Results may not apply to all people with knee osteoarthritis.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 138 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * both sexes * between 40 years old and 75 years old * with a clinical diagnosis of unilateral KOA * Who has had knee pain for more than 3 months * With a minimum score of 3 points on the numerical pain scale * Morning stiffness for less than 30 minutes * Crepitus * Bone tenderness and absence of palpable heat Exclusion Criteria: * Hip OA * Severe osteoporosis * Fibromyalgia * Clinical history of tumors or cancer * Active inflammatory joint diseases (rheumatoid arthritis, gout) * Undergoing any joint replacement in the lower extremity * Neurological diseases (Parkinson's disease, stroke * Multiple sclerosis * muscular dystrophies * Diseases involving motor neurons * Alzheimer's disease * Infected wounds or osteomyelitis in the knee region * Deep vein thrombosis or thrombophlebitis * Sensory alteration in the lower limbs * Cognitive and cardiopulmonary impairment that may prevent or limit the execution of exercises * Use of a walking assistance device * History of recent knee trauma * Having undergone any form of treatment involving physical therapy * intra-articular corticosteroids * anti-inflammatory drugs * opioid medication or chondroprotective in the six months before the start of the interventions

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis, knee

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Nove de Julho

    RECRUITING

    São Paulo, 01504-001, Brazil

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