Scientists test two methods to make skin red on purpose
NCT ID NCT07179263
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested two methods—applying a strong acid or repeatedly sticking and removing tape—to cause skin redness in 44 healthy women. Researchers measured how red the skin got and how long the redness lasted. The goal was to find a reliable way to create redness for future skin irritation studies.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- 50% glycolic acid
- What this could lead to
- If successful, this could help researchers develop better ways to test skin irritation treatments.
- What could go wrong
- This is a small, early-stage study in healthy volunteers, not a treatment trial. The methods may not work the same in people with skin conditions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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44 people
The number who actually took part.
- Started
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Dec 2023
- Finished
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Dec 2023
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 60 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Chinese female whose age range from 18 to 60 years old; 2. Be in general good health and good mental state; 3. Have no any broken, scars, birthmarks and other imperfections on the test area; 4. Redness/erythema ≥ grade 2 after modelling inducing (to ensure the consistency of the baseline for comparison); 5. Haven't applied Alpha hydroxyl acid in the past 3 months; 6. Not currently be participating in any other study involving the test area (Face and Forearm); 7. Not have participated in any other study involving the test area in the past one month; 8. Be willing to read, understand and able to sign the Informed Consent Form and Photo Release From; 9. Be willing to comply with all study protocol requirements. Exclusion Criteria: 1. Intending to get pregnant, be pregnant, be lactating, be within 6 months of delivery or be unwilling to take necessary precautions to avoid a pregnancy; 2. Having used antihistamine drugs in the past 1 week or immunosuppressants in the past 1 month; 3. Take anti-allergic drug/injections in the past 1 month; 4. Presently have allergies, allergic dermatitis or skin disease; 5. Have sensitivity or even allergy to topical products, ingredients or fragranced products; 6. Have history of allergies; 7. Have history of suffering from skin diseases (such as psoriasis, eczema, psoriasis, skin cancer, etc.); 8. Have used any anti-inflammatory treatment on the test area within 2 months prior to this study starting date; 9. Has a chronic medical condition that may interfere with testing (e.g., asthma, insulin-dependent diabetes, lupus, rheumatoid arthritis or other immune/auto-immune diseases); 10. Have used any scrubs or peeling product (regardless of method) or self-tanning products or oil control products in the past 3 days; 11. Have received cosmetic medical procedures on the face (such as injectable anti-wrinkle products, cosmetic surgery, tattoo removal, home light facial procedures or home use medical devices, etc.) in the past 1 month; 12. Have excessive sun exposure or ultraviolet light in the past 1 month; 13. Have applied ortho-hydroxybenzoic acid, hydroquinone in the past 3 months; or used prescriptions (such as antibiotic, retinoids, alpha hydroxyl acid and steroid), oral contraceptives (such as Diane 35®,Jasmine®, Holgyeme®,Syndi 35®,Regulon®); 14. Avoid providing emergency contact; 15. Subjects that are not compliant to the selection criteria or not proper for participation as determined by Principal Investigator; 16. An employee of the cosmetic companies or Shanghai China-Norm Quality technical service Co., Ltd.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Shanghai China-norm Quality Technical Service Co., Ltd.
Shanghai, Shanghai Municipality, 200072, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.