Cancer combo trial pulled before it even started
NCT ID NCT05982522
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study was designed to test a new oral drug called IN10018 combined with chemotherapy (nab-paclitaxel) and an immunotherapy (tislelizumab) in people with advanced solid tumors, specifically non-small cell lung cancer, that had stopped responding to prior treatments. The goal was to see if the combination could shrink tumors and to find the safest dose. However, the trial was withdrawn before enrolling any participants, so no data were collected.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- IN10018 (a drug taken by mouth) combined with nab-paclitaxel (chemotherapy) and tislelizumab (immunotherapy)
- What this could lead to
- If it works, this combination could offer a new treatment option for people with advanced solid tumors that have stopped responding to standard therapies.
- What could go wrong
- The trial was withdrawn before enrolling any participants, so no results are available. It is unclear if the combination is safe or effective.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 1/2
Runs two stages together: safety and dose first, then whether the treatment works.
- Expected to start
-
Aug 2025
An estimate. Start dates often move.
- Expected to finish
-
Dec 2026
An estimate. End dates often move.
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 75 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Male or female aged 18-75 years old at the time of signing informed consent. 2. Be able to understand and be willing to sign informed consent. 3. Histologically or cytologically confirmed NSCLC, which is not suitable for locallly radical therapy. Note: Subjects should have received prior platinum-based doublet chemotherapy and anti-PD-1/L1-based systemic therapy and failed in treatment. 4. Subjects who have failed in 1- to 2 prior lines of standard systemic therapy. 5. Has at least one measurable tumor lesion per RECIST 1.1. 6. Has an ECOG performance status of 0 or 1. 7. Estimated life expectancy is more than 3 months. 8. Has adequate organ function. 9. AEs due to prior antitumor therapy must be recovered to ≤ Grade 1 (CTCAE v5.0) or a steady state as assessed by investigators 10. Subjects (male and female) with childbearing potential must agree to use contraception during the treatment phase and through 3 months after the last dose of study treatment. Exclusion Criteria: 1. Previously documented EGFR, ALK and ROS1 mutation. 2. Have received chemotherapy, biological therapy, endocrine therapy, immunotherapy and other antitumor drugs within 4 weeks prior to the first dose of study treatment. 3. Have received other antitumor investigational drugs or treatments within 4 weeks prior to the first dose of study treatment. 4. Have received radiotherapy within 14 days prior to the first dose of study treatment. 5. Have had allogeneic haematopoietic stem cell transplantation or organ transplantation. 6. History of autoimmune disease within the past 2 years. 7. Have an immunodeficiency disorder or have received systemic steroid therapy (prednisone or equivalent corticosteroid \> 10 mg/day) or other immunosuppressants within 7 days prior to the first dose of study treatment. 8. Currently have interstitial pneumonitis. 9. Have had FAK inhibitors treatment. 10. Have received prior nab-paclitaxel treatment and the first documented disease progression/recurrence is within 6 months since the last dose of nab-paclitaxel treatment. 11. Malignancies other than the study disease within 3 years prior to the first dose of study treatment. 12. Active central nervous system (CNS) metastases and/or carcinogenic meningitis. 13. Has a history of severe cardiovascular or cerebrovascular diseases within 6 months prior to the first dose. 14. Pleural, pericardial or abdominal effusion that are clinically symptomatic and require puncture or drainage. 15. Any active infection requiring systemic therapy within 14 days prior to the first dose of study treatment. 16. Has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the study. Note: Subjects who have experienced Grade ≥ 3 immuno-related AEs (irAEs) during prior immunotherapy will not be enrolled.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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