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Does the Body's immune reaction to spine surgery differ by scoliosis type?

NCT ID NCT07734467

Knowledge-focused Sponsor: Ambrish Patel Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 29, 2026 · Last updated Aug 07, 2026 · Updated 3 times

Summary

This study investigates whether children and adults with neuromuscular scoliosis have a stronger immune response after spinal fusion surgery compared to those with idiopathic scoliosis. Researchers will analyze blood samples taken before and after surgery to measure immune markers. The goal is to understand why patients with neuromuscular scoliosis often need more fluids during recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If differences in immune response are found, it could lead to better understanding of why some patients need more fluid during surgery.
What could go wrong
This is a very small observational study, so results may not apply to all patients. It only looks at biomarkers, not direct outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Idiopathic or neuromuscular scoliosis undergoing posterior spinal fusion

Ages

0 to 99 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Any patient undergoing a posterior spinal fusion, regardless of age (birth to adult) * any patient with a diagnosis of idiopathic or neuromuscular scoliosis Exclusion Criteria: * Patient taking immunomodulators (monoclonal antibodies, chemotherapeutic agents) * chronic steroid use

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Conditions

The condition(s) this trial relates to.

idiopathic scoliosis scoliosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Idiopathic scoliosis Neuromuscular scoliosis Posterior spinal fusion

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Nationwide Children's Hospital

    Columbus, Ohio, 43205, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.