Timing matters: study tests best moment to remove dead tissue in pancreatitis
NCT ID NCT05530772
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at 50 adults with infected, walled-off dead tissue in the pancreas from severe pancreatitis. Researchers compared doing endoscopic removal right away versus waiting until needed. The goal was to see which approach leads to complete recovery and fewer complications.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Endoscopic necrosectomy (a procedure using an endoscope to remove dead tissue from the pancreas)
- What this could lead to
- If immediate necrosectomy works better, it could shorten hospital stays and reduce the number of procedures needed for patients with infected pancreatic necrosis.
- What could go wrong
- This is a small, single-center study with only 50 participants, so results may not apply to all patients. The procedure carries risks like bleeding, infection, or perforation.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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50 people
The number who actually took part.
- Started
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Sep 2022
- Finished
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Jun 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Documented history of acute pancreatitis * Necrotic collection with partial or complete wall diagnosed on CT or MRI * Necrotic collection of any size with any number of loculations with more than 20% of solid/necrotic component * Necrotic collection is accessible and amenable for EUS-guided drainage * Age \>= 18 years * Suspected or confirmed infection in the necrotic collection * The patient understands and accepts to sign the informed consent. Exclusion Criteria: * Irreversible coagulopathy with INR\>1.5 or platelet counts \<50,000 * Necrotic collection is not accessible for EUS-guided drainage * Females who are pregnant * Previous intervention (e,g, percutaneous drainage, or surgery) is performed for the patient
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Digestive Diseases Research Institute, Shariati Hospital, North Kargar Ave.,
Tehran, Tehran Province, 1411713135, Iran
More trials for these conditions
Other studies related to the condition(s) this trial covers.