New drug combo IDB-011 tested for safety against rift valley fever
NCT ID NCT06925919
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial is testing the safety of a new drug combination called IDB-011 in 40 healthy adults. The goal is to see if it is safe and how the body processes it, as a first step toward possibly preventing Rift Valley Fever, a viral disease spread by mosquitoes. Participants receive either the drug or a placebo, and researchers monitor for side effects and measure drug levels in the blood.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- IDB-011 (a combination of two drugs: IDB-774 and IDB-898)
- What this could lead to
- If this early safety study goes well, it could pave the way for a preventive treatment against Rift Valley Fever, a serious viral disease.
- What could go wrong
- This is a very early Phase 1 trial with only 40 healthy people. It only tests safety and how the drug moves in the body, not whether it actually prevents disease. Many drugs fail at this stage.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
-
About 40 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Apr 2025
- Expected to finish
-
Oct 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 64 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Healthy male or female * Body mass index (BMI) within 18.0 kg/m2 to 30.0 kg/m\^2, inclusively * Female participants must not be pregnant, breastfeeding or intend to become pregnant through 1 year post-administration * Male subjects must agree to not cause pregnancy or donate sperm for 1 year post-administration * Non-smoker * Agree to abstain from alcohol for 72 hours and caffeine for 48 hours prior to administration and during the confinement period * Agree to not donate blood or plasma during study participation * Agree not to travel to Rift Valley fever virus (RVFV) endemic areas during participation Exclusion Criteria: * Known history of RVFV infection * Previous receipt of RVFV vaccine * Illness with fever within 5 days prior to administration * History of malignancy within prior 5 years * History of significant cardiovascular, pulmonary, gastrointestinal, liver, kidney, hematologic, neurological, psychiatric, endocrine, immunologic, dermatologic disease * History of hypersensitivity reaction * History or clinical evidence of alcohol abuse * Human immunodeficiency virus (HIV) positive * Hepatitis C virus positive * Hepatitis B virus positive * Received immunoglobulin or antibody product within 6 months of administration * Vaccine within 28 days of administration * Received investigational agent within 3 months or \< 5 half-lives (whichever is longer) prior to administration * Donation of plasma, 1 unit or \> 500 mL blood donation in 56 days prior to administration
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Altasciences Clinical Los Angeles
Cypress, California, 90630, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.