Dye test may reveal hidden blood flow after filler mishaps
NCT ID NCT07581652
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at whether indocyanine green angiography (ICGA), a dye-based imaging test, can help doctors assess blood flow in the face after a rare but serious complication from hyaluronic acid filler injections. Researchers reviewed medical records and images from 19 patients who had already received treatment for a blocked artery. The goal was to see if ICGA could provide real-time information on tissue perfusion and help predict recovery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- indocyanine green angiography (ICGA)
- What this could lead to
- If successful, this could show that ICGA is a useful tool for doctors to quickly see how well blood flow is returning after treatment for a blocked artery from filler injections.
- What could go wrong
- This is a very small, retrospective study (19 people) that only looks back at existing data. It cannot prove that ICGA improves patient outcomes, only that it might be helpful for assessment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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19 people
The number who actually took part.
- Started
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Jul 2025
- Finished
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Mar 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study population consists of consecutive patients treated at the Center for Wound Repair and Tissue Regeneration, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, for facial vascular embolism following hyaluronic acid injection between July 2025 and March 2026. Participants will be identified retrospectively from existing medical records, indocyanine green angiography imaging data, treatment records, and follow-up documentation generated during routine clinical care.
- Ages
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18 years and older
- Sex
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Anyone
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * History of facial hyaluronic acid injection. * Clinical diagnosis of facial vascular embolism after hyaluronic acid injection, with symptoms or signs such as pain, skin color change, livedo-like discoloration, delayed capillary refill, or tissue ischemia. * Received initial rescue treatment at the study center. * Had indocyanine green angiography imaging performed before and immediately after initial rescue treatment as part of routine clinical care. * Had sufficient medical records and follow-up information available to assess subsequent treatment and tissue outcomes. Exclusion Criteria: * Incomplete indocyanine green angiography imaging data. * Insufficient medical records or follow-up information to assess the main study outcomes. * Missing key clinical information needed for study analysis. * Duplicate records or records with concerns about data reliability. * The patient or legal representative explicitly objected to the use of historical clinical data for this study, if applicable under local ethics requirements.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Plastic Surgery Hospital, Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, 100144, China