Can a glowing dye stop leaks after colon surgery?
NCT ID NCT07826156
First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time
Summary
Researchers are testing whether a dye called indocyanine green helps surgeons see blood flow in the bowel during laparoscopic colorectal surgery. The dye is injected before the bowel is cut, and near-infrared light makes the blood supply visible. The trial compares this method with standard visual checks in 120 adults who need elective surgery with a reconnection of the bowel. The goal is to see whether the dye-guided approach reduces serious leaks at the reconnection site over 90 days.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- indocyanine green, a dye injected into the bloodstream and viewed with near-infrared light to check blood flow in the bowel
- What this could lead to
- If it works, this could give surgeons a clearer way to choose where to cut the bowel, which may lower the chance of a leak after surgery.
- What could go wrong
- The dye may not change outcomes compared with standard visual checks, and it can rarely cause allergic reactions or a drop in blood pressure. The trial is limited to elective laparoscopic surgery in adults.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
120 people
The number who actually took part.
- Started
-
Aug 2025
- Finished
-
Sep 2026
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults aged 18 years or older. * Undergoing elective laparoscopic colorectal resection. * Planned primary colorectal anastomosis. * Able and willing to provide written informed consent. Exclusion Criteria: * Known allergy to iodine or indocyanine green. * Severe hepatic dysfunction. * Severe renal dysfunction. * Emergency colorectal resection. * Inflammatory bowel disease requiring extensive resection. * Previous colorectal surgery involving the planned anastomotic site.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Colorectal anastomotic leak are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Alexandria Main University Hospital
Alexandria, Egypt