New hope for stubborn melanoma? drug targets cancer growth enzymes
NCT ID NCT02581930
First seen Nov 01, 2025 · Last updated Apr 30, 2026 · Updated 22 times
Summary
This study tested a drug called ibrutinib in 18 people with stage IV melanoma that had not responded to prior therapy. Ibrutinib works by blocking certain enzymes that help cancer cells grow. The main goal was to see if the drug could shrink tumors, and researchers also looked at how long it kept the cancer from growing and how long people lived. This was a small, early-phase trial to gather information on effectiveness and resistance.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Case Western Reserve University
Cleveland, Ohio, 44106, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Los Angeles General Medical Center
Los Angeles, California, 90033, United States
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
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UCHealth University of Colorado Hospital
Aurora, Colorado, 80045, United States
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UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, 27599, United States
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USC / Norris Comprehensive Cancer Center
Los Angeles, California, 90033, United States
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University of California Davis Comprehensive Cancer Center
Sacramento, California, 95817, United States
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University of Kentucky/Markey Cancer Center
Lexington, Kentucky, 40536, United States
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University of Virginia Cancer Center
Charlottesville, Virginia, 22908, United States
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University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, 53792, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
Conditions
Explore the condition pages connected to this study.