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New drug iberdomide takes on lenalidomide in battle to keep myeloma at bay
NCT ID NCT05827016
First seen Jun 25, 2026 · Last updated Sep 18, 2026 · Updated 4 times
Summary
This phase 3 trial tests whether iberdomide is better than lenalidomide as maintenance therapy after a stem cell transplant in people newly diagnosed with multiple myeloma. About 1,200 participants will receive either drug to see which one delays cancer progression longer. The study is currently recruiting.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- iberdomide (compared to lenalidomide)
- What this could lead to
- If iberdomide works better than lenalidomide, it could help keep multiple myeloma from coming back longer after a stem cell transplant.
- What could go wrong
- This is a large phase 3 trial, but iberdomide may not prove superior to lenalidomide, and side effects could be similar or worse. Both drugs require ongoing treatment, so this is not a cure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
-
1,230 people
The number who actually took part.
- Started
-
Jun 2023
- Expected to finish
-
Jan 2036
An estimate. End dates often move.
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria * Confirmed diagnosis of symptomatic multiple myeloma (MM). * Eastern Cooperative Oncology Group performance status (ECOG) score of 0, 1, or 2. * Received 3 to 6 cycles of an induction therapy that includes a proteasome inhibitor (PI) and immunomodulatory (IMiD) \[eg, bortezomib thalidomide and dexamethasone (VTd), lenalidomide, bortezomib and dexamethasone (RVd)\] with or without a CD38 monoclonal antibody, daratumumab + bortezomib/thalidomide/dexamethasone \[D-VTd\] and daratumumab + bortezomib/ lenalidomide/dexamethasone \[D-VRd\]), or VCd / daratumumab + bortezomib/cyclophosphamide/dexamethasone \[D-VCd\], and followed by a single or tandem autologous stem cell transplantation (ASCT). Post-stem cell transplant consolidation is permitted. * Participants within 12 months (single transplant) or 15 months (tandem transplant) from initiation of induction therapy who achieved at least a partial response (PR) after autologous stem cell transplantation (ASCT) with or without consolidation, according to International Myeloma Working Group (IMWG 2016) criteria. Exclusion Criteria * Progressive disease or clinical relapse (as defined by IMWG response criteria) following ASCT with or without consolidation or is not responsive to primary therapy. * Smoldering myeloma, solitary plasmacytoma or nonsecretory myeloma. * Known central nervous system/meningeal involvement of MM. * Prior history of malignancies, other than MM, unless the participant has been free of the disease for ≥ 5 years. * Other protocol-defined Inclusion/Exclusion criteria apply.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Carl-Thiem-Klinikum Cottbus GmbH
Cottbus, Brandenburg, 03048, Germany
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Hanusch-Krankenhaus
Vienna, 1140, Austria
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Hospital Clínic de Barcelona
Barcelona, B, 08036, Spain
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Instituto Português Oncologia do Porto Francisco Gentil, EPE
Porto, 4200-072, Portugal
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Klinikum Bayreuth GmbH
Bayreuth, Bavaria, 95445, Germany
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LMU Klinikum der Universitaet Muenchen - Campus Grosshadern - Transplantation
Munich, Bavaria, 81377, Germany
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Local Institution - 0001
Ann Arbor, Michigan, 48109-5000, United States
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Local Institution - 0002
Cleveland, Ohio, 44195, United States
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Local Institution - 0003
Weston, Florida, 33331-3609, United States
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Local Institution - 0004
Nashville, Tennessee, 37203-1625, United States
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Local Institution - 0005
Charlotte, North Carolina, 28803-2493, United States
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Local Institution - 0006
Houston, Texas, 77030, United States
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Local Institution - 0007
Jacksonville, Florida, 32224-1865, United States
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Local Institution - 0009
Dallas, Texas, 75390-0001, United States
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Local Institution - 0011
Philadelphia, Pennsylvania, 19111-2433, United States
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Local Institution - 0012
Philadelphia, Pennsylvania, 19107, United States
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Local Institution - 0013
Toledo, Ohio, 43623, United States
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Local Institution - 0017
Kansas, Ohio, 64132, United States
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Local Institution - 0018
Atlanta, Georgia, 30322-1013, United States
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Local Institution - 0019
Athens, Georgia, 30607-1465, United States
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Local Institution - 0020
New York, New York, 10032-3729, United States
-
Local Institution - 0021
Augusta, Georgia, 30912, United States
-
Local Institution - 0023
Braga, 4710-243, Portugal
-
Local Institution - 0024
Kayseri, 38039, Turkey (Türkiye)
-
Local Institution - 0025
London, W1G 6AF, United Kingdom
-
Local Institution - 0026
Hamm, 59073, Germany
-
Local Institution - 0027
Hadera, 38100, Israel
-
Local Institution - 0028
Odense, 5000, Denmark
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Local Institution - 0029
Oxford, OX4 6LB, United Kingdom
-
Local Institution - 0030
Amiens, 80000, France
-
Local Institution - 0032
Yenimahalle, 06200, Turkey (Türkiye)
-
Local Institution - 0034
Sankt Pölten, 3100, Austria
-
Local Institution - 0035
Charleroi, WHT, 6060, Belgium
-
Local Institution - 0036
Brno, 625 00, Czechia
-
Local Institution - 0037
Berlin, State of Berlin, 12203, Germany
-
Local Institution - 0038
Jena, 07747, Germany
-
Local Institution - 0039
Katowice, 40-519, Poland
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Local Institution - 0040
Tübingen, 72076, Germany
-
Local Institution - 0043
Craiova, Dolj, 200143, Romania
-
Local Institution - 0044
Lublin, 20-134, Poland
-
Local Institution - 0046
Roma, RM, 00168, Italy
-
Local Institution - 0047
Haifa, 3109601, Israel
-
Local Institution - 0048
Kortrijk, 8500, Belgium
-
Local Institution - 0050
Créteil, 94000, France
-
Local Institution - 0051
Toulouse, 31059, France
-
Local Institution - 0052
Edirne, 22030, Turkey (Türkiye)
-
Local Institution - 0053
Catania, CT, 95123, Italy
-
Local Institution - 0054
Lille, 59037, France
-
Local Institution - 0055
Caen, 14033, France
-
Local Institution - 0057
Ashdod, 7747629, Israel
-
Local Institution - 0058
Linz, 4020, Austria
-
Local Institution - 0059
Lodz, Łódź Voivodeship, 93-510, Poland
-
Local Institution - 0060
Jerusalem, 9112001, Israel
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Local Institution - 0062
Debrecen, HB, 4032, Hungary
-
Local Institution - 0063
Thessaloniki, 546 39, Greece
-
Local Institution - 0064
Cluj-Napoca, Jud. Cluj, 400015, Romania
-
Local Institution - 0069
Prague, 128 08, Czechia
-
Local Institution - 0070
Dordrecht, 3300 AK, Netherlands
-
Local Institution - 0071
Milan, MI, 20162, Italy
-
Local Institution - 0072
Cluj-Napoca, 400015, Romania
-
Local Institution - 0073
Izmir, 35575, Turkey (Türkiye)
-
Local Institution - 0074
Naples, 80131, Italy
-
Local Institution - 0075
Jerusalem, 91031, Israel
-
Local Institution - 0077
Qingdao, 266071, China
-
Local Institution - 0078
Clayton, Victoria, 3800, Australia
-
Local Institution - 0079
Guangzhou, 511363, China
-
Local Institution - 0081
Ribeirão Preto, São Paulo, 14051-140, Brazil
-
Local Institution - 0082
Rio de Janeiro, Rio de Janeiro, 20230-130, Brazil
-
Local Institution - 0083
Porto Alegre, 90880-480, Brazil
-
Local Institution - 0084
Wuhan, 430030, China
-
Local Institution - 0087
Wenzhou, 325000, China
-
Local Institution - 0088
Adelaide, South Australia, 5000, Australia
-
Local Institution - 0091
Changchun, JL, 130021, China
-
Local Institution - 0093
Valledupar, 200001, Colombia
-
Local Institution - 0094
Shenyang, Liaoning, 110022, China
-
Local Institution - 0096
Rio de Janeiro, 21941-913, Brazil
-
Local Institution - 0097
Rio, G, 265 04, Greece
-
Local Institution - 0098
Salvador, 40110-150, Brazil
-
Local Institution - 0099
Vitacura, 7650567, Chile
-
Local Institution - 0100
Beijing, 100020, China
-
Local Institution - 0101
Floridablanca, 681004, Colombia
-
Local Institution - 0104
Nagasaki, 852-8511, Japan
-
Local Institution - 0105
Sapporo, 003-0006, Japan
-
Local Institution - 0106
Shibukawa-shi, Gunma, 3770280, Japan
-
Local Institution - 0108
Petah Tikva, 49100, Israel
-
Local Institution - 0109
Kochi, Kerala, 68202, India
-
Local Institution - 0110
Bangalore, Karnataka, 560027, India
-
Local Institution - 0111
Kagoshima, 890-8520, Japan
-
Local Institution - 0112
Hiroshima, 730-8619, Japan
-
Local Institution - 0113
Goyang-si, 410-769, South Korea
-
Local Institution - 0114
Seoul, 06351, South Korea
-
Local Institution - 0115
Genova, GE, 16132, Italy
-
Local Institution - 0116
Shibuya-ku, 150-8935, Japan
-
Local Institution - 0117
Bucharest, B, 022328, Romania
-
Local Institution - 0118
Gifu, 500-8513, Japan
-
Local Institution - 0119
Warsaw, 02-781, Poland
-
Local Institution - 0121
Maebashi, 371-8511, Japan
-
Local Institution - 0122
Kōtoku, 135-8550, Japan
-
Local Institution - 0123
Pune, Maharashtra, 411 004, India
-
Local Institution - 0124
Bhubaneswar, Odisha, 751007, India
-
Local Institution - 0125
Kolkata, West Bengal, 700160, India
-
Local Institution - 0128
Chandigarh, Chandigarh, 160012, India
-
Local Institution - 0129
Amsterdam, North Holland, 1081 HV, Netherlands
-
Local Institution - 0130
Sunto-gun, Shizuoka, 411-8777, Japan
-
Local Institution - 0131
Ramat Gan, 52621, Israel
-
Local Institution - 0132
Sendai, 983-8520, Japan
-
Local Institution - 0137
Beer Ya'Aqov, 70300, Israel
-
Local Institution - 0138
Singapore, 119074, Singapore
-
Local Institution - 0139
Pisa, PI, 56127, Italy
-
Local Institution - 0140
Torino, TO, 10126, Italy
-
Local Institution - 0141
Chiba, 260-8677, Japan
-
Local Institution - 0142
Pune, Maharashtra, 411004, India
-
Local Institution - 0143
Nagoya, 467-8602, Japan
-
Local Institution - 0144
Kanazawa, 920-8641, Japan
-
Local Institution - 0145
Busan, 49241, South Korea
-
Local Institution - 0146
Toluca, State of Mexico, 50090, Mexico
-
Local Institution - 0148
Saitama-Shi, 330-0834, Japan
-
Local Institution - 0149
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-168, Poland
-
Local Institution - 0150
Minatoku, 105-8471, Japan
-
Local Institution - 0151
Coimbra, 3000-075, Portugal
-
Local Institution - 0152
Nagpur, Maharashtra, 440030, India
-
Local Institution - 0153
Kaohsiung City, 83301, Taiwan
-
Local Institution - 0154
Stoke-on-Trent, Staffordshire, ST4 6QG, United Kingdom
-
Local Institution - 0155
Murcia, MU, 30120, Spain
-
Local Institution - 0156
Derby, DBY, DE22 3NE, United Kingdom
-
Local Institution - 0158
Izmir, 35100, Turkey (Türkiye)
-
Local Institution - 0159
New Taipei City, 220, Taiwan
-
Local Institution - 0160
Edinburgh, EH4 2XU, United Kingdom
-
Local Institution - 0161
Windsor, Berkshire, SL4 3HD, United Kingdom
-
Local Institution - 0162
Bournemouth, DOR, BH7 7DW, United Kingdom
-
Local Institution - 0163
Pamplona, 31008, Spain
-
Local Institution - 0164
Palma de Mallorca, 07120, Spain
-
Local Institution - 0165
Tainan, 704, Taiwan
-
Local Institution - 0166
Oviedo, Principality of Asturias, 33011, Spain
-
Local Institution - 0167
Ankara, 06230, Turkey (Türkiye)
-
Local Institution - 0169
Cáceres, CC, 10003, Spain
-
Local Institution - 0172
Las Palmas de Gran Canaria, Las Palmas, 35019, Spain
-
Local Institution - 0173
Aberdeen, ABD, AB25 2ZN, United Kingdom
-
Local Institution - 0174
Valencia, VC, 46026, Spain
-
Local Institution - 0175
Kaohsiung City, 82445, Taiwan
-
Local Institution - 0179
Medellín, 050034, Colombia
-
Local Institution - 0180
New York, New York, 10016-6402, United States
-
Local Institution - 0182
Córdoba, X5000JHGQ, Argentina
-
Local Institution - 0183
Ciudad Autonoma Buenos Aires, Buenos Aires F.D., C1199ABB, Argentina
-
Local Institution - 0185
Athens, I, 106 76, Greece
-
Local Institution - 0186
Santiago, 7500691, Chile
-
Local Institution - 0187
Singapore, 169608, Singapore
-
Local Institution - 0188
Milan, MI, 20122, Italy
-
Local Institution - 0190
Barretos, 14784-400, Brazil
-
Local Institution - 0191
Morristown, New Jersey, 07960, United States
-
Local Institution - 0192
Tampa, Florida, 33612-9416, United States
-
Local Institution - 0193
Dallas, Texas, 75246, United States
-
Local Institution - 0194
São Paulo, São Paulo, 05403-000, Brazil
-
Local Institution - 0195
Gdansk, 80-214, Poland
-
Local Institution - 0196
Hefei, AH, 230001, China
-
Local Institution - 0197
Kamakura-Shi, Kanagawa, 2478533, Japan
-
Local Institution - 0198
Kumamoto, Kumamoto, 860-8556, Japan
-
Local Institution - 0199
Isehara-shi, 259-1193, Japan
-
Local Institution - 0200
Kolhāpur, Maharashtra, 416005, India
-
Local Institution - 0201
Kuopio, 70211, Finland
-
Local Institution - 0202
Aurora, Colorado, 80012-5405, United States
-
Local Institution - 0203
Eugene, Oregon, 97401, United States
-
Local Institution - 0205
Clinton, Maryland, 20735-4230, United States
-
Local Institution - 0206
Olomouc, 779 00, Czechia
-
Local Institution - 0207
Hattiesburg, Mississippi, 39401, United States
-
Local Institution - 0208
Ottawa, Ontario, K1H 8L6, Canada
-
Local Institution - 0209
Thessaloniki, B, 570 10, Greece
-
Local Institution - 0210
Québec, Quebec, Canada
-
Local Institution - 0211
Bogotá, 110131, Colombia
-
Local Institution - 0212
Jinan, 250021, China
-
Local Institution - 0214
Niterói, Rio de Janeiro, 24020-096, Brazil
-
Local Institution - 0215
Prague, 100 34, Czechia
-
Local Institution - 0216
Beijing, 100044, China
-
Local Institution - 0217
Bogotá, 110111, Colombia
-
Local Institution - 0219
Paris, 75012, France
-
Local Institution - 0220
Box Hill, Victoria, 3128, Australia
-
Local Institution - 0221
Limoges, 87042, France
-
Local Institution - 0223
Shanghai, 200025, China
-
Local Institution - 0224
Iași, IS, 700483, Romania
-
Local Institution - 0225
Ulsan, 44033, South Korea
-
Local Institution - 0227
Ciudad Autonoma Buenos Aires, Buenos Aires F.D., C1430EFA, Argentina
-
Local Institution - 0228
Paris, 75013, France
-
Local Institution - 0229
Beijing, Beijing Municipality, 100071, China
-
Local Institution - 0230
Borås, 501 82, Sweden
-
Local Institution - 0231
Nanjing, 210029, China
-
Local Institution - 0232
Badalona, 08916, Spain
-
Local Institution - 0233
Athens, 115 28, Greece
-
Local Institution - 0234
Changsha, 400011, China
-
Local Institution - 0236
La Roche-sur-Yon, 85000, France
-
Local Institution - 0237
Chicago, Illinois, 60637-1426, United States
-
Local Institution - 0238
Cincinnati, Ohio, 45236-2725, United States
-
Local Institution - 0239
Xuzhou, Jiangsu, 221000, China
-
Local Institution - 0240
Jinan, SD, 250012, China
-
Local Institution - 0241
São Paulo, São Paulo, 08270-070, Brazil
-
Local Institution - 0242
Chongqing, Chongqing Municipality, 400016, China
-
Local Institution - 0243
Hangzhou, ZJ, 310003, China
-
Local Institution - 0244
Waratah, 2298, Australia
-
Local Institution - 0246
Zhengzhou, Henan, 450003, China
-
Local Institution - 0248
Wuhan, 430022, China
-
Local Institution - 0249
Tianjin, Tianjin Municipality, 300060, China
-
Local Institution - 0250
Hong Kong, HK, 000000, Hong Kong
-
Local Institution - 0252
Gliwice, 44-102, Poland
-
Local Institution - 0253
Pittsburgh, Pennsylvania, 15232, United States
-
Local Institution - 0256
Shenzhen, Guangdong, 518028, China
-
Local Institution - 0257
Detroit, Michigan, 48202-2610, United States
-
Local Institution - 0258
Temuco, 4800827, Chile
-
Local Institution - 0261
Guangzhou, Guangdong, 510080, China
-
Local Institution - 0262
Changsha, HN, 410013, China
-
Local Institution - 0263
Nanchang, Jiangxi, 330200, China
-
Local Institution - 0265
Xi'an, Shaanxi, 710032, China
-
Local Institution - 0266
Nanjing, Jiangsu, 210008, China
-
Local Institution - 0267
Pilar, B, B1629AHJ, Argentina
-
Local Institution - 0268
Sakaishi, 590-0197, Japan
-
Local Institution - 0270
Edmonton, Alberta, T6G 1Z2, Canada
-
Local Institution - 0272
Nantes, 44093, France
-
Local Institution - 0273
Fuzhou, 350001, China
-
Local Institution - 0274
Westbury, New York, 11590-5119, United States
-
Local Institution - 0276
Helsinki, 00290, Finland
-
Local Institution - 0277
São Paulo, São Paulo, 04537-080, Brazil
-
Local Institution - 0278
Pavia, 27100, Italy
-
Local Institution - 0279
Worcester, Massachusetts, 01655, United States
-
Local Institution - 0281
Durham, North Carolina, 27705-3976, United States
-
Local Institution - 0282
Changsha, HN, 410013, China
-
Local Institution - 0283
Monterrey, Nuevo León, 64460, Mexico
-
Local Institution - 0284
Portsmouth, HAM, PO6 3LY, United Kingdom
-
Local Institution - 0286
Winston-Salem, North Carolina, 27103, United States
-
Local Institution - 0287
Çankaya, 06680, Turkey (Türkiye)
-
Local Institution - 0288
Mineola, New York, 11501, United States
-
Local Institution - 0289
Taoyuan, 333, Taiwan
-
Local Institution - 0290
Larissa, 411 10, Greece
-
Local Institution - 0291
Uddevalla, 451 51, Sweden
-
Local Institution - 0292
Taipei, 10002, Taiwan
-
Local Institution - 0293
Seongnam-si, Gyeonggi-do, 13620, South Korea
-
Local Institution - 0294
Germantown, Tennessee, 38138-1762, United States
-
Local Institution - 0295
Seoul, 03722, South Korea
-
Local Institution - 0296
Grand Rapids, Michigan, 49503, United States
-
Local Institution - 0297
Hamburg, 20246, Germany
-
Local Institution - 0299
Cleveland, Ohio, 44111, United States
-
Local Institution - 0300
Wooster, Ohio, 44691, United States
-
Local Institution - 0301
Mayfield Heights, Ohio, 44124, United States
-
Local Institution - 0302
Montería, COR, 230002, Colombia
-
Local Institution - 0303
Rochester, Minnesota, 55905, United States
-
Local Institution - 0304
Guangzhou, GD, 510515, China
-
Local Institution - 0305
Suzhou, 215006, China
-
Local Institution - 0306
Florence, FI, 50134, Italy
-
Local Institution - 0307
Montreal, Quebec, H3T 1E2, Canada
-
Local Institution - 0308
Tampa, Florida, 33606, United States
-
Local Institution - 0309
Istanbul, 34381, Turkey (Türkiye)
-
Local Institution - 0315
Hamburg, Free and Hanseatic City of Hamburg, 22763, Germany
-
Local Institution - 0316
Chemnitz, Saxony, 09116, Germany
-
Local Institution - 0317
Madrid, 28022, Spain
-
Local Institution - 0318
Xi'an, Shaanxi, 710061, China
-
Local Institution - 0319
Shanghai, SH, 200434, China
-
Local Institution - 0320
Ningbo, ZJ, 315010, China
-
Local Institution - 0321
Chongqing, CQ, 400030, China
-
Local Institution - 0322
Winston-Salem, North Carolina, 27157, United States
-
Local Institution - 0324
Augsburg, Bavaria, 86156, Germany
-
Local Institution - 0326
Beijing, BJ, 100038, China
-
Local Institution - 0327
Bydgoszcz, 85-048, Poland
-
Local Institution - 0328
Brooklyn, New York, 11220-3313, United States
-
Local Institution - 0329
Nerima-Ku, 179-0072, Japan
-
Local Institution - 0330
Itabashi-Ku, 173-8610, Japan
-
Local Institution - 0331
Charlotte, North Carolina, 28204, United States
-
Medizinische Universitaet Wien - Universitaetsklinik fuer Augenheilkunde und Optometrie
Vienna, 1090, Austria
-
Policlinico Umberto I
Rome, 00161, Italy
-
Universitaetsklinikum Erlangen - Medizinische Klinik 5
Erlangen, Bavaria, 91054, Germany
-
University of Kansas Cancer Center - The Richard and Annette Bloch Cancer Care Pavilion
Westwood, Kansas, 66205-2003, United States
-
Universitätsklinikum Freiburg
Freiburg im Breisgau, 79106, Germany
-
Universitätsklinikum Ulm
Ulm, Baden-Wurttemberg, 89081, Germany
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