New drug IASO-782 aims to tame immune attacks on blood cells

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 18-65 years 2. Clinically confirmed diagnosis of autoimmune thrombocytopenia (ITP) or warm autoimmune haemolytic anaemia (wAIHA) 3. Failure or relapse after at least 1 treatment for the study disease 4. Stable dose of immunosuppressants for 4 weeks before screening 5. Organ function or laboratory test is basically normal 6. Subjects of childbearing potential and their partners must use effective contraception for at least 2 weeks before administration of investigational product, throughout the trial period, and for 28 days after the end of the trial (or early termination of the trial) 7. Females of potential childbearing capacity must have a negative pregnancy test at screening 8. Voluntarily participate in this study and sign the informed consent Exclusion Criteria: 1. History of other primary malignant neoplasm within 5 years of screening 2. Secondary to other disease-induced hematopoietic destruction 3. Cardiac disorder within the last 3 months 4. Patients with high blood pressure that cannot be controlled by drug 5. Subjects with a history of allergy to any component of the investigational drug 6. Active infection requiring intravenous treatment within 30 days prior to the enrollment 7. Pregnant or breastfeeding women 8. Participation was being given other investigational drug within 30 days or 5 half-lives (whichever is longer) prior to administration of the investigational drug 9. Previous treatment drugs have not been adequately washed out 10. ITP patients have had any previous arterial or venous thrombosis 11. Patients with ITP had previous biopsy bone marrow results indicating bone marrow fibrosis (Myelofibrosis MF) ≥ 2 12. Uncontrolled infection with human immunodeficiency virus (HIV), hepatitis B virus (HBV), or hepatitis C (HCV) infection; or diagnosis of immunodeficiency that is related to, or results in chronic infection, as described in the protocol 13. Subjects with a history of drug abuse or mental disorder 14. Other medical history or conditions that would make the subject unsuitable for the study by investigators' judge.