Can a quick scope procedure help women get pregnant faster after miscarriage?

NCT ID NCT04804332

Disease control Sponsor: University Hospital, Ghent Source: ClinicalTrials.gov ↗

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

After a miscarriage treated without surgery, some women still have leftover pregnancy tissue in the womb. This trial tests whether removing that tissue with a small camera-guided procedure (operative hysteroscopy) helps women become pregnant sooner compared to simply waiting and monitoring. The study includes women under 40 who want to try for another baby within six months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: operative hysteroscopy
What this could lead to: If operative hysteroscopy proves better than waiting, it could help women conceive sooner after a miscarriage and reduce the need for additional treatments.
What could go wrong: This is a relatively small trial, and the benefits of hysteroscopy over expectant management may be modest. The procedure carries typical surgical risks like infection or bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 244 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2021

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 39 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients after first trimester miscarriage treated non-surgically with sonographic evidence for the presence of RPOC at follow-up visit after 6 weeks (± 1 week) who have an immediate future pregnancy wish and are willing to give informed consent. Exclusion Criteria: * Women aged below 18 years * Women aged over 39 years * Women not wanting to achieve pregnancy within the first 6 months after non-surgical treatment for miscarriage * Women with a history of repeated miscarriage defined as 3 or more consecutive pregnancy losses before 20 weeks of pregnancy duration * Women with untreated and/or untreatable subfertility * Women presenting with severe uterine bleeding, defined as uterine bleeding that needs acute intervention on medical grounds * Women presenting with severe abdominal pain, defined as abdominal pain that needs acute intervention on medical grounds * Women with fever (\> 38.5° Celsius) or sepsis requiring antibiotic treatment. For the definition of 'sepsis' we refer to the Third International Consensus definitions for Sepsis and Septic Shock (Singer 2016) * Women with a contraindication for (office) operative hysteroscopy * Women with a failed non-surgical management for miscarriage, as substantiated by the sonographic finding of an intact gestational sac still in situ * Women with a congenital uterine anomaly * Known cervical stenosis making safe uterine access impossible * Visual or pathological (e.g. on biopsy) evidence of malignancy

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Retained products of conception

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

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Can a quick scope procedure help women get pregnant faster after miscarriage?

What the study statuses mean