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Could a simple pill make endoscopy smoother?
NCT ID NCT07271303
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a capsule form of hyoscine butylbromide (Buscopan) can reduce stomach and intestinal movements during painless gastrointestinal endoscopy, potentially improving the doctor's view and procedure accuracy. The trial will involve 74 adults scheduled for upper endoscopy, comparing the drug to a placebo. The main goal is to see if the pill reduces peristalsis (natural gut movements) without the need for injections.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- hyoscine butylbromide (Buscopan) capsules
- What this could lead to
- If it works, this could offer a pill that reduces stomach movement during endoscopy, making the procedure easier and less painful for patients.
- What could go wrong
- This is a small, early-stage trial with only 74 participants, so results may not apply to everyone. The drug may cause side effects like dry mouth or blurred vision.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 74 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Feb 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥18 years and ≤75 years, regardless of sex; * Patients scheduled to undergo painless gastrointestinal endoscopy examination or endoscopic surgery, which must include upper gastrointestinal endoscopy; * Voluntary participation based on the free will of the subject or their legal guardian, with signed informed consent form. Exclusion Criteria: * Patients with a history of upper gastrointestinal surgery or colorectal surgery; * American Society of Anesthesiologists (ASA) classification ≥ Grade III; * Patients with severe cardiac conditions, including severe arrhythmia, structural heart disease, or other serious cardiac disorders; * Significant hepatic or renal dysfunction affecting drug metabolism, defined as ALT \> 2.5 × ULN, AST \> 2.5 × ULN, or Scr \> 1.5 × ULN; * Organic pyloric stenosis, paralytic ileus, or other severe organic gastrointestinal diseases that are unsuitable for painless gastrointestinal endoscopy; * Patients with suspected gastrointestinal ulcer bleeding or perforation; * Patients with glaucoma or prostatic hypertrophy; * Pregnant or lactating women; * Known hypersensitivity to any component of the study drug; * Use of medications affecting gastrointestinal motility within 7 days prior to study enrollment; * Other conditions unsuitable for painless endoscopy procedures; * Participation in another drug or medical device clinical trial within 30 days prior to study enrollment; * Patients deemed unsuitable for participation in this clinical study by the investigator.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.