Can a special drink keep you more hydrated than water?
NCT ID NCT06981468
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested two versions of a low-sodium drink containing whey protein and glycerol to see if they help the body hold onto more fluid than plain water. Forty-three healthy adults took part in a crossover trial where each person tried both drinks and water on separate days. Researchers measured how much fluid the body retained after two hours.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- low-sodium beverage with whey protein and glycerol
- What this could lead to
- If it works, this could point toward better hydration strategies for athletes or people who need to stay hydrated.
- What could go wrong
- This is a small, early-stage study in healthy adults, so results may not apply to other groups. The beverage is not a treatment for any disease.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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43 people
The number who actually took part.
- Started
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Apr 2025
- Finished
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Jun 2025
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 50 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Female and male adults aged 18-50 years. 2. Body mass index (BMI) between 18.5 to 25 kg/m² (inclusive). 3. Healthy as determined based on self-reported medical history. 4. Able to understand and to sign a written informed consent prior to study enrolment. 5. Willing and able to comply with the requirements for participation in this study. Exclusion Criteria: 1. Any past or on-going diagnosed medical/surgical condition (e.g. malignancy, renal condition, liver condition, uncontrolled diabetes mellitus, cardiovascular disease, hypertension, migraine and headache disorders) and/ or psychiatric condition (e.g. depression, psychotic disorders, chronic insomnia, eating disorder), which in the opinion of the site physician/investigator may risk participant's well-being/safety, impede participant compliance with study procedures or ability to complete the study and/or could confound the primary objectives of the study. 2. Current intake of medication/s that impact hydration status (e.g. anti-hypertensive medications, anti-diabetic medications, anti-psychotics, anti-depressants, diuretics, laxatives, antidiuretic hormone (ADH) antagonists, oral corticosteroids, glucocorticoids, anti-cholinergic medications, or cyclosporine A). 3. Currently on a high-protein (1.5g/kg/BW/day) or ketogenic diet (based on self-report). 4. Known/suspected food allergy or intolerance to any food (based on self-report). 5. Female participants who are pregnant, lactating and/or breastfeeding (self-report or if in doubt, via urine pregnancy test). 6. Any self-reported chronic alcohol or drug abuse within the past year; specifically, an average alcohol intake \> 2 standard drinks per day over a week for males, and \> 1 standard drink per day over a week for females. One standard drink contains 10-12 g of ethanol, i.e., 0.3 dl of strong alcohols, 1dl of wine, 3 dl of beer. 7. Currently participating in another interventional study. 8. Family or hierarchical relationships with the research team members.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Clinical Innovation Lab, Nestlé Research
Lausanne, Switzerland
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