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New pain combo could ease kidney stone recovery

NCT ID NCT07102771

Symptom relief Sponsor: Kasr El Aini Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding hyaluronidase to a common numbing drug (bupivacaine) improves pain control after kidney stone surgery. 100 adults undergoing the procedure received an ultrasound-guided nerve block with or without hyaluronidase. The goal was to see if the combination reduces pain scores and improves recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
hyaluronidase added to bupivacaine
What this could lead to
If it works, this could lead to better pain relief after kidney stone surgery, reducing the need for strong painkillers.
What could go wrong
This is a small, completed study with 100 patients. The results may not apply to everyone, and adding hyaluronidase might not improve pain control significantly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

100 people

The number who actually took part.

Started

Jan 2025

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Elective percutaneous nephrolithotomy 2. Age: adult patients between 20 - 65 years old. 3. Gender: Both male and female. 4. ASA Class: I and II. Exclusion Criteria: 1. Refusal of patient. 2. Patients ASA class III and IV. 3. Chronic kidney disease grade lll \& lV . 4. Pregnancy and lactation. 5. Allergy to any of the study medications. 6. Addicts and drug abusers. 7. Patients taking corticosteroids or any cardio - active drugs. 8. Severe coagulopathy ( INR \>3 or platelets \<70\*10) . 9. Fever or sepsis. 10. Local infection at site of the injection.

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Conditions

The condition(s) this trial relates to.

nephrolithiasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Erector spinae plane block, nephrolithotomy, hyaluronidase

Contacts and locations

Locations

  • Kasr Alainy Hospitals

    Cairo, Cairo Governorate, 1234, Egypt

More trials for these conditions

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