Gum grafting without surgery? a trial tests natural substances to thicken tissue around implants
NCT ID NCT07750756
First seen Aug 06, 2026 · Last updated Aug 18, 2026 · Updated 5 times
Summary
This trial is testing whether adding hyaluronic acid or injectable platelet-rich fibrin (i-PRF) to a standard microneedling procedure can thicken the gum tissue around dental implants in the front of the mouth. The study includes people with thin gums (1 mm or less) around delayed implants in the aesthetic zone. Participants will be randomly assigned to receive microneedling alone, microneedling with hyaluronic acid, or microneedling with i-PRF, and the main goal is to see which approach produces the greatest increase in gum thickness.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Hyaluronic acid or injectable platelet-rich fibrin (i-PRF), each combined with microneedling
- What this could lead to
- If successful, this could point toward a more effective way to thicken gum tissue around dental implants, improving both aesthetics and long-term implant health.
- What could go wrong
- This is a small, early-stage trial, so results may not apply to everyone. The procedure carries typical risks like swelling, bruising, or infection, and the added benefit of these substances over microneedling alone is not yet proven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2/3
Runs two stages together: whether the treatment works, then large-scale confirmation.
- Participants
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About 42 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2026
An estimate. Start dates often move.
- Expected to finish
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May 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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21 to 50 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients with delayed implants placed in the maxillary esthetic region in correct positioning and angulation * Patients with peri-implant gingival thickness ≤ 1 mm * Patients with healthy gingiva and who can maintain good oral hygiene around implants Exclusion Criteria: * Marginal bone loss ≤ 2 mm * Patients with peri-implantitis or periodontitis * Patients with systemic conditions or diseases impairing healing or soft tissue metabolism * Pregnant or lactating females * Patients taking medications affecting the gingiva
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
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