New drug aims to slow devastating brain disease

NCT ID NCT05686551

Ongoing Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

Summary

This study is testing whether an experimental drug called tominersen can slow down Huntington's disease. It involves 301 people who either have very early symptoms or are at high risk of developing them. The drug is designed to lower the levels of a harmful protein in the brain that causes the disease, and researchers will measure its safety and if it helps with symptoms over 16 months.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Addenbrookes Hospital

Cambridge, CB2 0QQ, United Kingdom
Azienda Ospedaliera Sant'Andrea

Rome, Lazio, 00189, Italy
Barrow Neurological Institute

Phoenix, Arizona, 85013, United States
Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
CHU Angers, Batiement Larrey 2, Neurologie

Angers, 49933, France
CHU Strasbourg Hpital Hautepierre

Strasbourg, 67098, France
CHU de la Timone - Hopital d Adultes

Marseille, 13005, France
CHU toulouse - Hôpital Purpan

Toulouse, 31059, France
CINME

Buenos Aires, C1056ABI, Argentina
CNS - Campus Neurológico

Torres Vedras, 2560-280, Portugal
CenExel Rocky Mountain Clinical Research, LLC

Englewood, Colorado, 80113, United States
Chapel Allerton Hospital

Leeds, LS7 4SA, United Kingdom
Charité - Universitätsmed. Berlin, Klinik für Psychiatrie und Psychotherapie

Berlin, 10117, Germany
Dent Neurological Institute

Amherst, New York, 14226, United States
EvergreenHealth Investigational Drug Services

Kirkland, Washington, 98034, United States
Fondazione IRCCS Istituto Neurologico Carlo Besta

Milan, Lombardy, 20133, Italy
Georgetown University

Washington D.C., District of Columbia, 20007, United States
German Center for Neurodegenerative Diseases (DZNE)

Bonn, 53127, Germany
Groupe Hospitalier Pellegrin

Bordeaux, 33076, France
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Hopital Gui de Chauliac

Montpellier, 34295, France
Hopital Henri Mondor

Créteil, 94010, France
Hopital Roger Salengro Service de Neurologie

Lille, DUMMY_VALUE, France
Hospital Britanico de Buenos Aires

Ciudad Autonoma Buenos Aires, C1284AEB, Argentina
Hospital Ramon y Cajal

Madrid, 28034, Spain
Hospital Ramos Mejía

CABA, C1221ADC, Argentina
Hospital Universitario Virgen Macarena

Seville, 41009, Spain
Hospital Universitario de Badajoz

Badajoz, 06080, Spain
Hospital Universitario de Burgos. Servicio de Neurología

Burgos, 09006, Spain
Hospital Universitario la Fe

Valencia, 46026, Spain
Hospital de Cruces

Barakaldo, Vizcaya, 48903, Spain
Hospital de Santa Maria

Lisbon, 1649-035, Portugal
Hospital de la Santa Creu i Sant Pau

Barcelona, 08041, Spain
INEBA

Capital Federal, C1192AAX, Argentina
Inland Northwest Research

Spokane, Washington, 99202, United States
John Hopkins University School of Medicine

Baltimore, Maryland, 21287, United States
John Radcliffe Hospital

Oxford, OX3 9DU, United Kingdom
Krakowska Akademia Neurologii Sp z o.o. Centrum Neurologii K

Krakow, 31-505, Poland
Monash Medical Centre

Clayton, Victoria, 3168, Australia
Montreal Neurological Inst

Montreal, Quebec, H3A 2B4, Canada
Neurozentrum Siloah

Gümligen, 3073, Switzerland
New Zealand Brain Research Institute

Christchurch, 8011, New Zealand
Northwestern University

Chicago, Illinois, 60611, United States
Ospedale Bellaria

Bologna, Emilia-Romagna, 40139, Italy
Perron Institute for Neurological and Translational Science

Nedlands, Western Australia, 6009, Australia
Rigshospitalet, Hukommelsesklinikken

København Ø, 2100, Denmark
Royal Melbourne Hospital

Parkville, Victoria, 3050, Australia
Southampton University Hospitals NHS Trust

Southampton, SO16 6YD, United Kingdom
St. Josef-Hospital, Neurologische Klinik der Ruhr-Uni

Bochum, 44791, Germany
Szpital Sw. Wojciecha

Gdansk, 80-462, Poland
The University of Texas Health Science Center at Houston

Houston, Texas, 77030, United States
UCL Hospital NHS Trust

London, NW1 2PG, United Kingdom
Uab Medicine

Birmingham, Alabama, 35294, United States
Uniklinik RWTH Aachen

Aachen, 52074, Germany
Uniklinik fuer Neurologie, Medizinische Universitaet Innsbruck

Innsbruck, 6020, Austria
University Hospitals Birmingham NHS Foundation Trust

Birmingham, B15 2TH, United Kingdom
University of Alberta Hospital

Edmonton, Alberta, T6G 2G3, Canada
University of California Davis Medical System

Sacramento, California, 95817, United States
University of Florida

Gainesville, Florida, 32608, United States
University of Iowa Hospitals and Clinics

Iowa City, Iowa, 52242, United States
University of Pittsburgh

Pittsburgh, Pennsylvania, 15213, United States
University of South Florida

Tampa, Florida, 33612, United States
Universitätsklinikum Erlangen, Abteilung Molekulare Neurologie

Erlangen, 91054, Germany
Universitätsklinikum Schleswig-Holstein / Campus Lübeck

Lübeck, 23538, Germany
Universitätsklinikum Ulm

Ulm, 89081, Germany
Universitätsspital Basel

Basel, 4031, Switzerland
Vanderbilt University Medical Center

Nashville, Tennessee, 37212, United States
Waikato Hospital

Hamilton, 3240, New Zealand
Wojskowy Instytut Medycyny Lotniczej

Warsaw, 01-755, Poland
kbo - Isar-Amper-Klinikum Taufkirchen

Taufkirchen, 84416, Germany

Conditions

Explore the condition pages connected to this study.

HUNTINGTON DISEASE