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Can exercise rewire nerves to strengthen bones? new study investigates

NCT ID NCT07253493

Knowledge-focused Sponsor: Istanbul Physical Medicine Rehabilitation Training and Research Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how mechanical loading, like standing or vibrating, affects spinal reflexes in postmenopausal women with and without osteoporosis. Researchers will measure nerve signals (H-reflex) under different loads to see if bone loss changes these responses. The goal is to understand the body's hidden wiring that links exercise to bone health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could reveal how weight-bearing exercises help bones, potentially guiding better osteoporosis treatments.
What could go wrong
This is a small, early-stage observational study with only 24 participants. It measures reflexes, not health outcomes, so direct benefits are uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 24 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Apr 2026

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Being in the postmenopausal period * For the osteoporosis group: having femoral osteoporosis (femoral neck or total femur T-score ≤ -2.5) * For the control group: having no osteoporosis or osteopenia (femoral neck and total femur T-scores \> -1, and L1-L4 and L2-L4 T-scores \> -1) * Being a volunteer Exclusion Criteria: * Receiving osteoporosis treatment * Having a peripheral or central nervous system disorder (e.g., stroke, polyneuropathy, radiculopathy, entrapment neuropathy, etc.) * Having acquired or hereditary muscle diseases (myopathies) * Having active painful lower extremity pathologies (e.g., osteoarthritis, inflammatory joint diseases, etc.) * Having cardiac arrhythmias * Having a history of other metabolic bone diseases * Having skin lesions at the electrode placement sites on the lower extremities * Being older than 65 years

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Conditions

The condition(s) this trial relates to.

osteoporosis postmenopausal osteoporosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoporosis postmenopausal

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Istanbul Physical Medicine Rehabilitation Training & Research Hospital

    RECRUITING

    Bahçelievler, Istanbul, 34180, Turkey (Türkiye)

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