Hormone shield? study tests if progesterone or testosterone can prevent dangerous heart rhythms

NCT ID NCT04675788

Completed Knowledge-focused Sponsor: Indiana University Source: ClinicalTrials.gov ↗

First seen Mar 31, 2026 · Last updated May 21, 2026 · Updated 7 times

Summary

This study looked at whether the hormones progesterone (in women) and testosterone (in men) can reduce the heart's sensitivity to a drug that can cause dangerous heart rhythm changes. Researchers gave 73 older adults either the hormone or a placebo, then a small dose of the heart-affecting drug ibutilide, and measured electrical changes in the heart. The goal was to see if these hormones could protect against drug-induced heart rhythm problems.

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Contacts and locations

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Locations

Indiana Clinical Research Center

Indianapolis, Indiana, 46202, United States
Indiana University

Indianapolis, Indiana, 46202, United States
Purdue University

Indianapolis, Indiana, 46202, United States

Conditions

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ABNORMALITIES, DRUG-INDUCED ABNORMALITIES, DRUG-INDUCED LONG QT SYNDROME LONG QT SYNDROME