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Can a supplement box turn back the clock? new study investigates

NCT ID NCT07548645

Knowledge-focused Sponsor: Human Optimization Project Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether a daily supplement called HOP Box can improve markers of biological aging and overall health in women. Thirty-five women aged 35 to 60 will take the supplement twice a day for 90 days. Researchers will measure changes in biological age using a blood test, track sleep and heart data with a wearable ring, and assess quality of life through surveys. There is no placebo group, so this is an early test to see if a larger study is worth doing.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
HOP Box dietary supplement (19 ingredients)
What this could lead to
If successful, this could point toward a supplement that supports healthy aging in women.
What could go wrong
This is a very small pilot study with no placebo group, so results may be due to chance or other factors. It is too early to draw firm conclusions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 35 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

35 to 60 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Women aged 35 to 60 years, English-speaking, and residing in the United States * Must own an Oura Ring with an active membership and a minimum of 30 days of baseline data * Willingness to comply with all study procedures, assessments, lifestyle considerations, and follow-ups for the study duration * Medically stable with no significant health changes in the past three months Exclusion Criteria: * Current use of GLP-1 receptor agonists (e.g., semaglutide, liraglutide), SGLT2 inhibitors (e.g., canagliflozin, dapagliflozin, empagliflozin), insulin, metformin, thiazolidinediones, acarbose, alpha-glucosidase inhibitors, or any investigational drug or supplement within the past 30 days * Current use of NAD+ precursors (nicotinamide riboside, NMN, niacin, NAD+), supplements containing active ingredients already in the HOP Box formulation, high-dose vitamin B12, berberine, alpha-lipoic acid, or other glucose-lowering supplements * Confirmed diagnosis of Type 1 or Type 2 diabetes, known liver disease (hepatitis, cirrhosis, NAFLD), kidney disease (including CKD or renal impairment), active or recent cancer (within past 5 years, excluding non-melanoma skin cancers), or severe psychiatric/mood disorders (bipolar disorder, schizophrenia, or major depressive disorder requiring hospitalization or intensive psychiatric intervention) * Known allergy, hypersensitivity, or intolerance to any active or inactive ingredient in the intervention * Participation in any other clinical trial, wellness intervention, or investigational product study within the 30 days prior to enrollment * Currently pregnant, breastfeeding, or planning to become pregnant within the next 12 months

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Longevity Women's health

Contacts and locations

Locations

  • Reputable Health

    Wilmington, Delaware, 19808, United States

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