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Pause the pill for better eggs? new trial investigates

NCT ID NCT07225660

Knowledge-focused Sponsor: Shady Grove Fertility Reproductive Science Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether pausing birth control pills for two months before egg freezing leads to better egg quality and quantity. Researchers will compare women who pause the pill to those who start egg freezing right away. The goal is to see if a short break can improve the number of mature eggs retrieved.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
pause of combined hormonal contraceptives (birth control pills)
What this could lead to
If successful, this could show that a short break from birth control before egg freezing leads to better egg yields, potentially improving fertility preservation outcomes.
What could go wrong
This is an early-stage trial with no phase designation, so results are uncertain. The intervention is simply a pause in medication, so dramatic improvements are unlikely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 394 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Ovary-bearing individuals 18 to 40 years of age. 2. BMI \< 40 kg/m2 3. Non-smoker for at least 3 months prior to study enrollment. Exclusion Criteria: 1. BMI greater than or equal to 40 kg/m2 2. Current Smoker 3. Any contraindications to ovarian stimulation or outpatient egg retrieval under anesthesia

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fertility preservation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    3 sites. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Reproductive Medicine Associates of New York

    NOT_YET_RECRUITING

    New York, New York, 10022, United States

    Contact Email: •••••@•••••

  • Shady Grove Fertility Rockville

    RECRUITING

    Rockville, Maryland, 20850, United States

    Contact Email: •••••@•••••

  • Yale Fertility Center

    RECRUITING

    Orange, Connecticut, 06477, United States

    Contact Email: •••••@•••••

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