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Twice-Yearly shot could revolutionize HIV prevention for young women

NCT ID NCT04994509

Ongoing Prevention Sponsor: Gilead Sciences Source: ClinicalTrials.gov ↗

First seen Apr 07, 2026 · Last updated May 24, 2026 · Updated 5 times

Summary

This study tested two ways to prevent HIV in over 5,000 adolescent girls and young women at risk of infection. One group received a twice-yearly injection of lenacapavir, while another took a daily pill (emtricitabine/tenofovir alafenamide). The goal was to see how well each method works compared to the expected infection rate in the community. Results will show if the long-acting shot is a safe and effective option for HIV prevention.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • AMBSO Masaka Clinical Research site

    Kyotera- Masaka Region, Uganda

  • Africa Health Research Institute

    Mtubatuba, 3935, South Africa

  • Botha's Hill Clinical Research Site, HIV Prevention Research Unit

    Durban, 3660, South Africa

  • CAPRISA Umlazi Clinical Research Site

    Umlazi, 4066, South Africa

  • CAPRISA Vulindlela Clinical Research Site

    Durban, 4001, South Africa

  • CAPRISA eThekwini Clinical Research Site

    Durban, 4001, South Africa

  • Chatsworth Clinical Research Site, South African Medical Research Council, HIV and Other Infectious Disease Research Unit

    Kwa Zulu Natal, South Africa

  • Desmond Tutu Health Foundation - Masiphumelele Research Office

    Sunnydale, 7705, South Africa

  • Desmond Tutu Health Foundation Clinical Trials Unit

    Cape Town, 7925, South Africa

  • Emavundleni Research Centre

    Cape Town, 7750, South Africa

  • FPD-DTHF Ndevana Community Research Site

    Vincent, 5217, South Africa

  • Madibeng Centre for Research

    Brits, 2500, South Africa

  • Makerere University- John Hopkins University (MU-JHU) Mityana Research Site (MU-JHU) Care Ltd

    Mityana Town, Uganda

  • Makerere-Kalangala Clinical Research site

    Kalangala, Uganda

  • MatCH Research Unit, Suite 1112, 11th Floor

    Durban, 4001, South Africa

  • Perinatal HIV Research Unit (PHRU) Soweto Kliptown

    Kliptown, 1809, South Africa

  • Phoenix Clinical Research Site, South African Medical Research Council, HIV and Other Infectious Disease Research Unit

    Kwa Zulu Natal, 4061, South Africa

  • Qhakaza Mbokodo Research Clinic

    Ladysmith, 3370, South Africa

  • Setshaba Research Centre

    Gauteng, 152, South Africa

  • Synergy Biomed Research Institute (SBRI)

    East London, South Africa

  • The Aurum Institute: Gavin J Churchyard Legacy Centre, Klerksdorp Clinical Research Centre

    Klerksdorp, 2571, South Africa

  • The Aurum Institute: Pretoria Clinical Research Centre

    Pretoria, 0087, South Africa

  • The Aurum Institute: Rustenburg Clinical Research Centre

    Rustenburg, 299, South Africa

  • The Aurum Institute: Tembisa Clinical Research Centre

    Tembisa, 1632, South Africa

  • Tongaat Clinical Research Site, South African Medical Research Council, HIV and Other Infectious Disease Research Unit

    Kwa Zulu Natal, 4400, South Africa

  • Verulam Clinical Research Site, South African Medical Research Council, HIV and Other Infectious Disease Research Unit

    Kwa Zulu Natal, 4340, South Africa

  • Vuka Research Clinic

    Cape Town, 7784, South Africa

  • Wits Reproductive Health & HIV Institute (Wits RHI)

    Johannesburg, 2038, South Africa

Conditions

Explore the condition pages connected to this study.

PRE-EXPOSURE PROPHYLAXIS OF HIV INFECTION