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Exercise secret revealed: histamine may be key to muscle adaptation

NCT ID NCT05206227

Knowledge-focused Sponsor: University of Oregon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how histamine, a chemical your body makes, helps muscles adapt to exercise. Researchers will measure histamine levels and muscle blood flow in 80 healthy adults aged 18-40 during and after exercise. The goal is to understand the body's natural response, not to test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2021

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 -40 Exclusion Criteria: * Systolic ≥ 120 * Diastolic ≥ 80 * Body mass index (BMI) ˃ 28 kg/m2 * Prior diagnosis of cardiovascular disease, diabetes, autonomic disorders, or asthma * Smoking or nicotine use * Ongoing medical therapy (other than birth control) * Ongoing use of over-the-counter or prescription antihistamines * Allergies or hypersensitivities to drugs, local anesthetics, skin disinfectants, adhesives, or latex * Pregnant, breastfeeding subjects, or planning to become pregnant in the next 12 months * Mobility restrictions that interfere with physical activity * High physical activity based on International Physical Activity Questionaire (IPAQ1) * Non-English speaking

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Conditions

The condition(s) this trial relates to.

Motor Activity Post-Exercise Hypotension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postexercise hypotension

Contacts and locations

Locations

  • University of Oregon

    Eugene, Oregon, 97403, United States