Hip implant showdown: which design keeps metals out of your blood?
NCT ID NCT03371212
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two types of hip replacement implants to see if one raises metal levels in the blood more than the other. Fifty-two adults getting a hip replacement will be randomly assigned to receive either a standard implant or a newer 'dual mobility' design. Researchers will measure cobalt, chromium, and titanium in participants' blood after surgery to check for differences.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- hip replacement implants (dual mobility vs. conventional)
- What this could lead to
- If successful, this study could help surgeons choose hip implants that minimize metal release into the blood.
- What could go wrong
- This is a small, early-phase study with only 52 participants, so results may not apply to everyone. It measures metal levels, not long-term health effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
-
About 52 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2017
- Expected to finish
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Dec 2036
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age between 18 and 80 years * Willingness to undergo serial postoperative venipuncture for serum meal analysis * BMI \< 40 * Patients that are eligible for the requisite implants as deemed by their surgeon Exclusion Criteria: * Clinically significant systemic chronic disease * Diminished renal function * Presence of any metal-containing implant outside of the oral cavity * History of prior hip surgery involving an internal fixation device * History of hip infection * Preoperative diagnosis other than osteoarthritis * Anticipated need for another joint replacement surgery within one year * Patients taking chromium supplements
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Rush University Medical Center
Chicago, Illinois, 60612, United States
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