New liquid viagra versions put to the test against popular ED pills
NCT ID NCT07117383
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage study will compare how two new liquid forms of sildenafil (Hezkue and Hezkue Turbo) are absorbed in the body versus several commercial ED products like Viagra and chewable tablets. Seventy-two healthy men will take single doses after a meal, and researchers will measure drug levels and side effects like headache or dizziness. The goal is to see if the new formulations offer any differences in absorption or tolerability.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- sildenafil (the active ingredient in Viagra)
- What this could lead to
- If successful, this could show that Hezkue or Hezkue Turbo are absorbed differently than other sildenafil products, potentially offering a new option for erectile dysfunction.
- What could go wrong
- This is an early Phase 1 study in only 72 healthy men, not people with erectile dysfunction. It only measures absorption and short-term side effects, not whether the drugs actually work for ED.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
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About 72 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jan 2026
An estimate. Start dates often move.
- Expected to finish
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Mar 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Male participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Participant must be informed of the nature of the study and voluntarily agree to participate by signing an informed consent form prior to any study-specific procedures. * Participant must be a healthy male, aged 18 to 70 years (inclusive) at the time of dosing. * Participant must be judged by the Investigator or designee to be in good general health, as documented by medical history, physical examination, clinical laboratory tests, vital signs, and 12-lead electrocardiogram (ECG). Any deviations from normal ranges must be assessed and deemed not clinically significant by the Investigator or designee. * Participant must have a creatinine clearance (CrCl) value greater than 80 mL/min, as calculated by the Cockcroft-Gault equation. * Participant must agree to practice an acceptable method of contraception throughout the clinical trial, as outlined in the protocol. Exclusion Criteria: * Unwilling or unable to comply with study procedures. * Use of any investigational drug (except Hezkue/Hezkue Turbo) within 30 days prior to dosing. * History of significant renal, hepatic, cardiovascular (including orthostatic hypotension), psychiatric, neoplastic, infectious disease, or diabetes mellitus. * Clinically significant abnormal lab results, vital signs, or ECGs. * Any hepatic impairment or abnormal liver function tests. * Positive test for hepatitis B surface antigen, hepatitis C antibody, or HIV antibody. * Clinically significant illness within 28 days prior to dosing. * Known hypersensitivity to sildenafil, tadalafil, vardenafil, or any component of the investigational product (e.g., peppermint oil). * History of significant food or drug allergies. * History of drug abuse within the past year or positive drug screen at screening. * Regular alcohol consumption exceeding 15 units per week. * Use of CYP450 enzyme inhibitors within 14 days prior to dosing. * Use of CYP450 enzyme inducers or St. John's Wort within 28 days prior to dosing. * Blood donation or significant blood loss within 3 months before screening. * Plasma donation within 14 days prior to first dose. * Inadequate venous access for repeated blood sampling. * Difficulty fasting or inability to consume standardized meals. * Intolerance to fatty foods or inability to consume a high-fat, high-calorie breakfast. * Difficulty swallowing. * Regular use of tobacco or nicotine products within 4 weeks prior to screening. * Major surgery within 3 months or minor surgery within 1 month before screening. * Considered unsuitable for study participation by the Investigator. * Institutionalized status. * Use of hormone replacement therapy within 6 months prior to dosing. * Consumption of Seville oranges, grapefruit, or pomelo within 7 days prior to dosing. * Consumption of caffeine, xanthine-containing products, or poppy seeds within 48 hours prior to dosing. * Receipt of a COVID-19 vaccine within 3 days prior to dosing. * Presence of braces, retainers, dentures, partial dentures, or tongue piercings. * Use of nitric oxide donors, organic nitrates/nitrites, antihypertensive medications, or PDE5 inhibitors within 14 days of dosing. * Blood pressure or heart rate outside acceptable ranges: * Systolic BP \<90 or \>140 mmHg * Diastolic BP \<50 or \>90 mmHg * Heart rate \<50 or \>100 bpm
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Aspargo Labs
New York, New York, 10004, United States
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