New drug shows promise for tough lung cancers in early trial
NCT ID NCT03260491
First seen Nov 01, 2025 · Last updated May 22, 2026 · Updated 30 times
Summary
This early-stage study tests an experimental drug called HER3-DXd in people with advanced non-small cell lung cancer (NSCLC) that has stopped responding to other treatments. The goal is to check the drug's safety and see if it can shrink tumors. The study includes patients with different genetic mutations, including EGFR and KRAS-G12C, who have run out of standard options.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Asan Medical Center
Seoul, 05505, South Korea
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Chung Shan Medical University Hospital
Taichung, 40705, Taiwan
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City of Hope
Duarte, California, 91010, United States
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Clinica Universidad Navarra(Madrid)
Madrid, 28027, Spain
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Clínica Universidad de Navarra (Pamplona)
Pamplona, 31008, Spain
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Fred Hutchinson Cancer Center
Seattle, Washington, 98109, United States
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Gabrail Cancer Center (GCC) - Canton Facility
Canton, Ohio, 44718-2566, United States
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Henry Ford Hospital
Detroit, Michigan, 48202, United States
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Hospital General Universitario Gregorio Maranon (HGUGM)
Madrid, 28007, Spain
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Hospital Ramón y Cajal
Madrid, 28034, Spain
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Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
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Hospital Universitario Madrid Sanchinarro - Centro Integral Oncologico Clara Campal (CIOCC)
Madrid, 28050, Spain
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Hospital Universitario Quirónsalud Madrid
Madrid, 28223, Spain
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Hospital Universitario Vall d'Hebron
Barcelona, 08035, Spain
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Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
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Kindai University Hospital
Osaka, 5898511, Japan
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Kurume University - Kurume University Hospital - Respiratory Diseases Center
Kurume-Shi, 830-0011, Japan
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Memorial Sloan-Kettering Cancer Center
New York, New York, 10065, United States
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NEXT Oncology - Hospital Quironsalud Barcelona
Barcelona, 08023, Spain
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NYU Langone Health - NYU Medical Oncology Associates
New York, New York, 10016-4744, United States
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National Cancer Center Hospital East (NCCHE) - Kashiwa Campus
Kashiwa-Shi, 277-8577, Japan
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National Cheng Kung University Hospital
Tainan, 00704, Taiwan
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National Taiwan University Hospital
Taipei, 00100, Taiwan
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Netherlands Cancer Institute
Amsterdam, 1066 CX, Netherlands
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Northwest Medical Specialties
Tacoma, Washington, 98405, United States
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Oncology Consultants P.A.
Houston, Texas, 77030, United States
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Pacific Shores Medical Group
Long Beach, California, 90813, United States
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Samsung Medical Center
Seoul, 06351, South Korea
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Sarah Cannon Research Institute/Tennesse Oncology
Nashville, Tennessee, 37203, United States
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Seoul National University Hospital
Seoul, 03080, South Korea
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Shizuoka Cancer Center
Shizuoka, 4118777, Japan
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The Cancer Institute Hospital of Japanese Foundation for Cancer Research (JFCR)
Tokyo, 1358550, Japan
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University of California San Diego
La Jolla, California, 92093, United States
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University of Pittsburgh Medical Center (UPMC) - Hillman Cancer Center (University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania, 15232-1301, United States
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Winship Cancer Institute of Emory University
Atlanta, Georgia, 30322, United States
Conditions
Explore the condition pages connected to this study.