Can a simple injection save Kids' hearing during chemo?
NCT ID NCT04478292
First seen May 05, 2026 · Last updated Jun 19, 2026 · Updated 7 times
Summary
This phase 3 trial tests whether sodium thiosulfate, given after cisplatin chemotherapy, can prevent hearing loss in children with hepatoblastoma (a rare liver cancer). About 330 children will be enrolled, some receiving the hearing-protecting drug and others not. The study also adjusts treatment intensity for children whose cancer has spread.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Shanghai Children's Medical Center
RECRUITINGShanghai, Shanghai Municipality, 200127, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Sodium thiosulfate (STS) given intravenously to protect hearing during cisplatin chemotherapy
What this could lead to
If successful, this could reduce permanent hearing loss in children treated for hepatoblastoma, improving their quality of life after cancer therapy.
What could go wrong
This is a large phase 3 trial, but sodium thiosulfate may not effectively prevent hearing damage in all children, and it could interfere with chemotherapy effectiveness. Results may not apply to all patient groups.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.