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New hope for kids with liver cancer: personalized treatment shows promise

NCT ID NCT00980460

Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 2 times

Summary

This study tests a treatment plan tailored to each child's risk level for a rare liver cancer called hepatoblastoma. About 236 children will receive standard treatments like surgery and chemotherapy, plus the drug temsirolimus for high-risk cases. The goal is to see if this approach improves survival and reduces side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

236 people

The number who actually took part.

Started

Sep 2009

Finished

Mar 2026

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Up to 21 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients must be newly diagnosed with histologically-proven hepatoblastoma * In emergency situations when a patient meets all other eligibility criteria and has had baseline required observations, but is too ill to undergo a biopsy safely, the patient may be enrolled on AHEP0731 without a biopsy * Clinical situations in which such emergent treatment may be indicated include, but are not limited to, the following circumstances: * Anatomic or mechanical compromise of critical organ function by tumor (e.g., respiratory distress/failure, abdominal compartment syndrome, urinary obstruction, etc) * Uncorrectable coagulopathy * For a patient to maintain eligibility for AHEP0731 when emergent treatment is given, the following must occur: * The patient must have a clinical diagnosis of hepatoblastoma, including an elevated alpha fetoprotein, and must meet all AHEP0731 eligibility criteria at the time of emergent treatment * Patient must be enrolled on AHEP0731 prior to initiating protocol therapy; a patient will be ineligible if any chemotherapy is administered prior to AHEP0731 enrollment * If the patient receives AHEP0731 chemotherapy PRIOR to undergoing a diagnostic biopsy, pathologic review of material obtained in the future during either biopsy or surgical resection must either confirm the diagnosis of hepatoblastoma or not reveal another pathological diagnosis to be included in the analysis of the study aims * Patients will be staged for risk classification and treatment at diagnosis using Children's Oncology Group (COG) staging guidelines * At the time of study enrollment, the patient's treatment regimen must be identified; if the patient's primary tumor was resected prior to the day of enrollment and a blood specimen for the determination of serum alpha fetoprotein was not obtained prior to that surgery, the patient will be considered to have alpha fetoprotein of greater than 100 ng/mL for the purpose of treatment assignment; if tumor samples obtained prior to the date of enrollment were not sufficient to determine whether small cell undifferentiated (SCU) histology was present, treatment assignment will be made assuming SCU is not present in the tumor * For patients with stage I or II disease, specimens for rapid central review have been submitted and the rapid central review diagnosis and staging must be available to be provided on the AHEP0731 eligibility case report form (CRF) * Patients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores 0, 1, or 2; use Karnofsky for patients \> 16 years of age and Lansky for patients =\< 16 years of age * Patients may have had surgical resection of some or all sites of hepatoblastoma prior to enrollment * Organ function requirements are not required for enrolled patients who are stage I, PFH and will not be receiving chemotherapy * Creatinine clearance or radioisotope glomerular filtration rate (GFR) \>= 70 mL/min/1.73 m\^2 OR serum creatinine based on age/gender as follows: * 1 month to \< 6 months: 0.4 mg/dL * 6 months to \< 1 year: 0.5 mg/dL * 1 to \< 2 years: 0.6 mg/dL * 2 to \< 6 years: 0.8 mg/dL * 6 to \< 10 years: 1 mg/dL * 10 to \< 13 years: 1.2 mg/dL * 13 to \< 16 years: 1.5 mg/dL (male) or 1.4 mg/dL (female) * \>= 16 years: 1.7 mg/dL (male) or 1.4 mg/dL (female) * Total bilirubin \< 1.5 x upper limit of normal (ULN) for age * Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase \[AST\]) or serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase \[ALT\]) \< 10 x ULN for age * Absolute neutrophil count (ANC) \> 750/uL * Platelet count \> 75,000/uL * Shortening fraction \>= 27% by echocardiogram * Ejection fraction \>= 47% by radionuclide angiogram (multi gated acquisition scan \[MUGA\]); Note: the echocardiogram (or MUGA) may be done within 28 days prior to enrollment * Serum triglyceride level =\< 300 mg/dL (=\< 3.42 mmol/L) * Serum cholesterol level =\< 300 mg/dL (7.75 mmol/L) * Random or fasting blood glucose within the upper normal limits for age; if the initial blood glucose is a random sample that is outside of the normal limits, then a follow-up fasting blood glucose can be obtained and must be within the upper normal limits for age * Normal pulmonary function tests (including diffusing capacity of the lungs for carbon monoxide \[DLCO\]) if there is clinical indication for determination (e.g. dyspnea at rest, known requirement for supplemental oxygen); Note: for patients who do not have respiratory symptoms or requirement for supplemental oxygen, pulmonary function tests (PFTs) are NOT required * Patients with seizure disorder may be enrolled if on non-enzyme inducing anticonvulsants and if seizures are well controlled * Prothrombin time (PT) \< 1.2 x ULN * All patients and/or their parents or legal guardians must sign a written informed consent * All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met Exclusion Criteria: * Patients with stage I or II disease who do not have specimens submitted for rapid central pathology review by day 14 after initial surgical resection * Patients that have been previously treated with chemotherapy for hepatoblastoma or other hepatoblastoma-directed therapy (e.g., radiation therapy, biologic agents, local therapy \[embolization, radiofrequency ablation, laser\]) are not eligible * Patients who have received any prior chemotherapy are not eligible * Patients who are currently receiving another investigational drug are not eligible * Patients who are currently receiving other anticancer agents are not eligible * Patients who have previously received a solid organ transplant are not eligible * Patients who have an uncontrolled infection are not eligible * Females who are pregnant or breast feeding are not eligible for this study * Female patients of childbearing potential are not eligible unless a negative pregnancy test result has been obtained * Males and females of reproductive potential are not eligible unless they have agreed to use an effective contraceptive method * Patients receiving corticosteroids are not eligible; patients must have been off corticosteroids for 7 days prior to start of chemotherapy * Patients who are currently receiving enzyme inducing anticonvulsants are not eligible * Patients must not be receiving any of the following potent cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4) inducers or inhibitors: erythromycin, clarithromycin, azithromycin, ketoconazole, itraconazole, voriconazole, posaconazole, grapefruit juice or St. John's wort * Patients who are currently receiving therapeutic anticoagulants (including aspirin, low molecular weight heparin, warfarin and others) are not eligible * Patients who are currently receiving angiotensin-converting enzymes (ACE) inhibitors are not eligible * Patients must not have had major surgery within 6 weeks prior to enrollment on the high risk stratum; patients with history of recent minor surgical procedures (vascular catheter placement, bone marrow evaluation, laparoscopic surgery, liver tumor biopsy) will be eligible

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Conditions

The condition(s) this trial relates to.

hepatoblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pretext I hepatoblastoma Pretext ii hepatoblastoma Pretext iii hepatoblastoma Pretext iv hepatoblastoma

Contacts and locations

Locations

  • AdventHealth Orlando

    Orlando, Florida, 32803, United States

  • Advocate Children's Hospital-Oak Lawn

    Oak Lawn, Illinois, 60453, United States

  • Advocate Children's Hospital-Park Ridge

    Park Ridge, Illinois, 60068, United States

  • Advocate Lutheran General Hospital

    Park Ridge, Illinois, 60068, United States

  • Albany Medical Center

    Albany, New York, 12208, United States

  • Alberta Children's Hospital

    Calgary, Alberta, T3B 6A8, Canada

  • Alfred I duPont Hospital for Children

    Wilmington, Delaware, 19803, United States

  • Alliance for Childhood Diseases/Cure 4 the Kids Foundation

    Las Vegas, Nevada, 89135, United States

  • Arkansas Children's Hospital

    Little Rock, Arkansas, 72202-3591, United States

  • Arnold Palmer Hospital for Children

    Orlando, Florida, 32806, United States

  • Ascension Saint Vincent Indianapolis Hospital

    Indianapolis, Indiana, 46260, United States

  • BI-LO Charities Children's Cancer Center

    Greenville, South Carolina, 29605, United States

  • Banner University Medical Center - Tucson

    Tucson, Arizona, 85719, United States

  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

    Houston, Texas, 77030, United States

  • Blank Children's Hospital

    Des Moines, Iowa, 50309, United States

  • British Columbia Children's Hospital

    Vancouver, British Columbia, V6H 3V4, Canada

  • Bronson Methodist Hospital

    Kalamazoo, Michigan, 49007, United States

  • Brooke Army Medical Center

    Fort Sam Houston, Texas, 78234, United States

  • Broward Health Medical Center

    Fort Lauderdale, Florida, 33316, United States

  • C S Mott Children's Hospital

    Ann Arbor, Michigan, 48109, United States

  • CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)

    Québec, G1V 4G2, Canada

  • CancerCare Manitoba

    Winnipeg, Manitoba, R3E 0V9, Canada

  • Carilion Children's

    Roanoke, Virginia, 24014, United States

  • Carolinas Medical Center/Levine Cancer Institute

    Charlotte, North Carolina, 28203, United States

  • Cedars-Sinai Medical Center

    Los Angeles, California, 90048, United States

  • Centre Hospitalier Universitaire Sainte-Justine

    Montreal, Quebec, H3T 1C5, Canada

  • Children's Healthcare of Atlanta - Arthur M Blank Hospital

    Atlanta, Georgia, 30329, United States

  • Children's Hospital Colorado

    Aurora, Colorado, 80045, United States

  • Children's Hospital Los Angeles

    Los Angeles, California, 90027, United States

  • Children's Hospital Medical Center of Akron

    Akron, Ohio, 44308, United States

  • Children's Hospital New Orleans

    New Orleans, Louisiana, 70118, United States

  • Children's Hospital and Medical Center of Omaha

    Omaha, Nebraska, 68114, United States

  • Children's Hospital of Alabama

    Birmingham, Alabama, 35233, United States

  • Children's Hospital of Eastern Ontario

    Ottawa, Ontario, K1H 8L1, Canada

  • Children's Hospital of Orange County

    Orange, California, 92868, United States

  • Children's Hospital of Philadelphia

    Philadelphia, Pennsylvania, 19104, United States

  • Children's Hospital of Pittsburgh of UPMC

    Pittsburgh, Pennsylvania, 15224, United States

  • Children's Hospital of San Antonio

    San Antonio, Texas, 78207, United States

  • Children's Hospital of The King's Daughters

    Norfolk, Virginia, 23507, United States

  • Children's Hospital of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Children's Hospitals and Clinics of Minnesota - Minneapolis

    Minneapolis, Minnesota, 55404, United States

  • Children's Mercy Hospitals and Clinics

    Kansas City, Missouri, 64108, United States

  • Children's National Medical Center

    Washington D.C., District of Columbia, 20010, United States

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, Ohio, 45229, United States

  • Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

  • Connecticut Children's Medical Center

    Hartford, Connecticut, 06106, United States

  • Cook Children's Medical Center

    Fort Worth, Texas, 76104, United States

  • Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital

    Grand Rapids, Michigan, 49503, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

    Lebanon, New Hampshire, 03756, United States

  • Dayton Children's Hospital

    Dayton, Ohio, 45404, United States

  • Dell Children's Medical Center of Central Texas

    Austin, Texas, 78723, United States

  • Driscoll Children's Hospital

    Corpus Christi, Texas, 78411, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • East Carolina University

    Greenville, North Carolina, 27834, United States

  • East Tennessee Childrens Hospital

    Knoxville, Tennessee, 37916, United States

  • Eastern Maine Medical Center

    Bangor, Maine, 04401, United States

  • El Paso Children's Hospital

    El Paso, Texas, 79905, United States

  • Fukushima Medical University Hospital

    Fukushima, Fukushima, 960-1295, Japan

  • Golisano Children's Hospital of Southwest Florida

    Fort Myers, Florida, 33908, United States

  • Greenville Cancer Treatment Center

    Greenville, South Carolina, 29605, United States

  • Hackensack University Medical Center

    Hackensack, New Jersey, 07601, United States

  • Henry Ford Health Saint John Hospital

    Detroit, Michigan, 48236, United States

  • Hiroshima University Hospital

    Hiroshima, 734-8551, Japan

  • Hospital for Sick Children

    Toronto, Ontario, M5G 1X8, Canada

  • Hurley Medical Center

    Flint, Michigan, 48503, United States

  • IWK Health Centre

    Halifax, Nova Scotia, B3K 6R8, Canada

  • Inova Fairfax Hospital

    Falls Church, Virginia, 22042, United States

  • Instituto De Oncologia Pediatrica

    São Paulo, 04023-062, Brazil

  • John Hunter Children's Hospital

    Hunter Regional Mail Centre, New South Wales, 2310, Australia

  • Johns Hopkins All Children's Hospital

    St. Petersburg, Florida, 33701, United States

  • Kagoshima University Medical Dental Hospital

    Kagoshima, Kagoshima-ken, 890-8520, Japan

  • Kaiser Permanente Downey Medical Center

    Downey, California, 90242, United States

  • Kaiser Permanente-Oakland

    Oakland, California, 94611, United States

  • Kalamazoo Center for Medical Studies

    Kalamazoo, Michigan, 49008, United States

  • Kapiolani Medical Center for Women and Children

    Honolulu, Hawaii, 96826, United States

  • Kingston Health Sciences Centre

    Kingston, Ontario, K7L 2V7, Canada

  • Laura and Isaac Perlmutter Cancer Center at NYU Langone

    New York, New York, 10016, United States

  • Lee Memorial Health System

    Fort Myers, Florida, 33901, United States

  • Legacy Emanuel Children's Hospital

    Portland, Oregon, 97227, United States

  • Legacy Emanuel Hospital and Health Center

    Portland, Oregon, 97227, United States

  • Loma Linda University Medical Center

    Loma Linda, California, 92354, United States

  • Loyola University Medical Center

    Maywood, Illinois, 60153, United States

  • Lucile Packard Children's Hospital Stanford University

    Palo Alto, California, 94304, United States

  • Lurie Children's Hospital-Chicago

    Chicago, Illinois, 60611, United States

  • Madigan Army Medical Center

    Tacoma, Washington, 98431, United States

  • Maine Children's Cancer Program

    Scarborough, Maine, 04074, United States

  • Mary Bridge Children's Hospital and Health Center

    Tacoma, Washington, 98405, United States

  • Massachusetts General Hospital Cancer Center

    Boston, Massachusetts, 02114, United States

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905, United States

  • McMaster Children's Hospital at Hamilton Health Sciences

    Hamilton, Ontario, L8N 3Z5, Canada

  • MedStar Georgetown University Hospital

    Washington D.C., District of Columbia, 20007, United States

  • Medical City Dallas Hospital

    Dallas, Texas, 75230, United States

  • Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

  • Memorial Health University Medical Center

    Savannah, Georgia, 31404, United States

  • Memorial Regional Hospital/Joe DiMaggio Children's Hospital

    Hollywood, Florida, 33021, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Mercy Children's Hospital

    Toledo, Ohio, 43608, United States

  • Mercy Hospital Saint Louis

    St Louis, Missouri, 63141, United States

  • Methodist Children's Hospital of South Texas

    San Antonio, Texas, 78229, United States

  • Miami Cancer Institute

    Miami, Florida, 33176, United States

  • Michigan State University

    East Lansing, Michigan, 48823, United States

  • Miller Children's and Women's Hospital Long Beach

    Long Beach, California, 90806, United States

  • Mission Hospital

    Asheville, North Carolina, 28801, United States

  • Montefiore Medical Center - Moses Campus

    The Bronx, New York, 10467, United States

  • Morristown Medical Center

    Morristown, New Jersey, 07960, United States

  • Mount Sinai Hospital

    New York, New York, 10029, United States

  • NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

    New York, New York, 10032, United States

  • NYU Langone Hospital - Long Island

    Mineola, New York, 11501, United States

  • National Cancer Center Hospital

    Tokyo, 104 0045, Japan

  • Nationwide Children's Hospital

    Columbus, Ohio, 43205, United States

  • Naval Medical Center -San Diego

    San Diego, California, 92134, United States

  • Nemours Children's Clinic - Orlando

    Orlando, Florida, 32806, United States

  • Nemours Children's Clinic - Pensacola

    Pensacola, Florida, 32504, United States

  • Nemours Children's Clinic-Jacksonville

    Jacksonville, Florida, 32207, United States

  • Nemours Children's Hospital

    Orlando, Florida, 32827, United States

  • Nevada Cancer Research Foundation NCORP

    Las Vegas, Nevada, 89120, United States

  • New York Medical College

    Valhalla, New York, 10595, United States

  • Newark Beth Israel Medical Center

    Newark, New Jersey, 07112, United States

  • Nicklaus Children's Hospital

    Miami, Florida, 33155, United States

  • Nihon University Itabashi Hospital

    Itabashi-ku, Tokyo, 173-8610, Japan

  • Norton Children's Hospital

    Louisville, Kentucky, 40202, United States

  • Novant Health Presbyterian Medical Center

    Charlotte, North Carolina, 28204, United States

  • OSF Children's Hospital of Illinois

    Peoria, Illinois, 61637, United States

  • Ochsner Medical Center Jefferson

    New Orleans, Louisiana, 70121, United States

  • Oregon Health and Science University

    Portland, Oregon, 97239, United States

  • Orlando Health Cancer Institute

    Orlando, Florida, 32806, United States

  • Overlook Hospital

    Summit, New Jersey, 07902, United States

  • Penn State Children's Hospital

    Hershey, Pennsylvania, 17033, United States

  • Phoenix Childrens Hospital

    Phoenix, Arizona, 85016, United States

  • Primary Children's Hospital

    Salt Lake City, Utah, 84113, United States

  • Princess Margaret Hospital for Children

    Perth, Western Australia, 6008, Australia

  • Prisma Health Richland Hospital

    Columbia, South Carolina, 29203, United States

  • Providence Sacred Heart Medical Center and Children's Hospital

    Spokane, Washington, 99204, United States

  • Rady Children's Hospital - San Diego

    San Diego, California, 92123, United States

  • Rainbow Babies and Childrens Hospital

    Cleveland, Ohio, 44106, United States

  • Rhode Island Hospital

    Providence, Rhode Island, 02903, United States

  • Riley Hospital for Children

    Indianapolis, Indiana, 46202, United States

  • Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center

    Denver, Colorado, 80218, United States

  • Roswell Park Cancer Institute

    Buffalo, New York, 14263, United States

  • Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital

    New Brunswick, New Jersey, 08903, United States

  • Saint Christopher's Hospital for Children

    Philadelphia, Pennsylvania, 19134, United States

  • Saint Joseph's Hospital/Children's Hospital-Tampa

    Tampa, Florida, 33607, United States

  • Saint Joseph's Regional Medical Center

    Paterson, New Jersey, 07503, United States

  • Saint Jude Children's Research Hospital

    Memphis, Tennessee, 38105, United States

  • Saint Luke's Cancer Institute - Boise

    Boise, Idaho, 83712, United States

  • Saint Mary's Medical Center

    West Palm Beach, Florida, 33407, United States

  • Saint Peter's University Hospital

    New Brunswick, New Jersey, 08901, United States

  • San Jorge Children's Hospital

    San Juan, 00912, Puerto Rico

  • Sanford USD Medical Center - Sioux Falls

    Sioux Falls, South Dakota, 57117-5134, United States

  • Santa Barbara Cottage Hospital

    Santa Barbara, California, 93102, United States

  • Saskatoon Cancer Centre

    Saskatoon, Saskatchewan, S7N 4H4, Canada

  • Scott and White Memorial Hospital

    Temple, Texas, 76508, United States

  • Seattle Children's Hospital

    Seattle, Washington, 98105, United States

  • Shizuoka Cancer Center

    Shizuoka, Suntou, 411-8777, Japan

  • Sinai Hospital of Baltimore

    Baltimore, Maryland, 21215, United States

  • Southern Illinois University School of Medicine

    Springfield, Illinois, 62702, United States

  • State University of New York Upstate Medical University

    Syracuse, New York, 13210, United States

  • Summerlin Hospital Medical Center

    Las Vegas, Nevada, 89144, United States

  • Sunrise Hospital and Medical Center

    Las Vegas, Nevada, 89109, United States

  • Sutter Medical Center Sacramento

    Sacramento, California, 95816, United States

  • T C Thompson Children's Hospital

    Chattanooga, Tennessee, 37403, United States

  • The Children's Hospital at TriStar Centennial

    Nashville, Tennessee, 37203, United States

  • The Children's Hospital at Westmead

    Westmead, New South Wales, 2145, Australia

  • The Montreal Children's Hospital of the MUHC

    Montreal, Quebec, H3H 1P3, Canada

  • The Steven and Alexandra Cohen Children's Medical Center of New York

    New Hyde Park, New York, 11040, United States

  • Tripler Army Medical Center

    Honolulu, Hawaii, 96859, United States

  • Tulane University School of Medicine

    New Orleans, Louisiana, 70112, United States

  • UCSF Benioff Children's Hospital Oakland

    Oakland, California, 94609, United States

  • UCSF Medical Center-Mission Bay

    San Francisco, California, 94158, United States

  • UCSF Medical Center-Parnassus

    San Francisco, California, 94143, United States

  • UF Health Cancer Institute - Gainesville

    Gainesville, Florida, 32610, United States

  • UMC Cancer Center / UMC Health System

    Lubbock, Texas, 79415, United States

  • UMass Memorial Medical Center - University Campus

    Worcester, Massachusetts, 01655, United States

  • UNC Lineberger Comprehensive Cancer Center

    Chapel Hill, North Carolina, 27599, United States

  • USA Health Strada Patient Care Center

    Mobile, Alabama, 36604, United States

  • UT Southwestern/Simmons Cancer Center-Dallas

    Dallas, Texas, 75390, United States

  • University Medical Center of Southern Nevada

    Las Vegas, Nevada, 89102, United States

  • University Pediatric Hospital

    San Juan, 00926, Puerto Rico

  • University of Alabama at Birmingham Cancer Center

    Birmingham, Alabama, 35233, United States

  • University of Arkansas for Medical Sciences

    Little Rock, Arkansas, 72205, United States

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California, 95817, United States

  • University of Chicago Comprehensive Cancer Center

    Chicago, Illinois, 60637, United States

  • University of Hawaii Cancer Center

    Honolulu, Hawaii, 96813, United States

  • University of Illinois

    Chicago, Illinois, 60612, United States

  • University of Iowa/Holden Comprehensive Cancer Center

    Iowa City, Iowa, 52242, United States

  • University of Kentucky/Markey Cancer Center

    Lexington, Kentucky, 40536, United States

  • University of Miami Miller School of Medicine-Sylvester Cancer Center

    Miami, Florida, 33136, United States

  • University of Minnesota/Masonic Cancer Center

    Minneapolis, Minnesota, 55455, United States

  • University of Mississippi Medical Center

    Jackson, Mississippi, 39216, United States

  • University of Missouri Children's Hospital

    Columbia, Missouri, 65212, United States

  • University of Nebraska Medical Center

    Omaha, Nebraska, 68198, United States

  • University of New Mexico Cancer Center

    Albuquerque, New Mexico, 87106, United States

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, 73104, United States

  • University of Rochester

    Rochester, New York, 14642, United States

  • University of Texas Health Science Center at San Antonio

    San Antonio, Texas, 78229, United States

  • University of Virginia Cancer Center

    Charlottesville, Virginia, 22908, United States

  • University of Wisconsin Carbone Cancer Center - University Hospital

    Madison, Wisconsin, 53792, United States

  • VCU Massey Comprehensive Cancer Center

    Richmond, Virginia, 23298, United States

  • Valley Children's Hospital

    Madera, California, 93636, United States

  • Vanderbilt University/Ingram Cancer Center

    Nashville, Tennessee, 37232, United States

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina, 27157, United States

  • Walter Reed National Military Medical Center

    Bethesda, Maryland, 20889-5600, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

  • Wayne State University/Karmanos Cancer Institute

    Detroit, Michigan, 48201, United States

  • West Virginia University Charleston Division

    Charleston, West Virginia, 25304, United States

  • West Virginia University Healthcare

    Morgantown, West Virginia, 26506, United States

  • Women's and Children's Hospital-Adelaide

    North Adelaide, South Australia, 5006, Australia

  • Yale University

    New Haven, Connecticut, 06520, United States