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New hope for hemophilia: experimental clotting factor shows promise in chinese trial

NCT ID NCT06738485

First seen Nov 21, 2025 · Last updated May 23, 2026 · Updated 19 times

Summary

This study tests a new recombinant clotting factor (rVIII-SingleChain) in 60 Chinese males with severe hemophilia A. Participants receive the treatment 2-3 times weekly to prevent bleeding episodes. The goal is to see how well it works and if it is safe, including checking for side effects like allergic reactions or inhibitors that block the treatment.

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Contacts and locations

Locations

  • Beijing Children's Hospital

    Beijing, Beijing Municipality, 100045, China

  • Children's Hospital of Chongqing Medical University

    Chongqing, Chongqing Municipality, 400014, China

  • Fujian Medical University Union Hospital

    Fuzhou, Fujian, 350001, China

  • Guangzhou Women and Children's Medical Center

    Guangzhou, Guangdong, 510623, China

  • Henan children's hospital Zhengzhou children's Hospital

    Zhengzhou, Henan, 450053, China

  • Hospital of Hematology, Chinese Academy of Medical Sciences

    Tianjin, Hebei, 300020, China

  • Hunan Provincial Children's Hospital

    Changsha, Hunan, 410021, China

  • Jiangxi Provincial People's Hospital

    Nanchang, Jiangxi, 212028, China

  • Jinan Central Hospital

    Jinan, Shandong, 250013, China

  • Liuzhou People's Hospital

    Liuzhou, Guangxi, 545006, China

  • Nanfang Hospital of Southern Medical University

    Guangzhou, Guangdong, 515399, China

  • Nanjing Children's Hospital

    Nanjing, Jiangsu, 210008, China

  • North China University of Science and Technology Affiliated Hospital

    Tangshan, Hebei, 63000, China

  • Qingdao Women and Children's Hospital

    Qingdao, Shandong, 266071, China

  • Quinghai Provincial People's Hospital

    Xining, Qinghai, 81000, China

  • Shanghai Jiaotong University School of Medicine, Ruijin Hospital

    Shanghai, Shanghai Municipality, 200020, China

  • The Children's Hospital Zhejiang University School of Medicine

    Hangzhou, Zhejiang, 310005, China

  • The Second Hospital of Anhui Medical University

    Hefei, Anhui, 230000, China

  • The second affiliated hospital of Kunming Medical University

    Kunming, Yunan, 650011, China

  • XuZhou Children's Hospital

    Xuzhou, Jiangsu, 221006, China

Conditions

Explore the condition pages connected to this study.