Dialysis showdown: which method cleans blood better in ICU patients?
NCT ID NCT01403220
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested two types of dialysis—hemodiafiltration and hemofiltration—in 163 ICU patients with acute kidney failure. Patients received both methods in alternating order, and researchers measured how well each reduced waste products like urea in the blood. The goal was to see which technique works better for critically ill patients.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- dialysis procedure (hemodiafiltration and hemofiltration)
- What this could lead to
- If one method works better, it could improve waste removal for ICU patients with acute kidney failure, potentially leading to better outcomes.
- What could go wrong
- This is a small, completed study comparing two techniques, not a new treatment. Results may not apply to all patients or settings.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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163 people
The number who actually took part.
- Start date
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Apr 2012
- Finished
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Mar 2015
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * According to RIFLE score, patient is stage 'F' * The patient must be insured or beneficiary of a health insurance plan * The patient meets at least one of the following criteria: * metabolic acidosis (pH \< 7.2), excluding keto-acidosis * plasma urea \> 25 mmol/l * hyper-hydration is not controlled by diuretics Exclusion Criteria: * Chronic, terminal renal insufficiency with dialysis * The patient is under judicial protection, under tutorship or curatorship * Suspect hyperkaliemia (Kaliemia \> 6.5 mmol/l with electrocardiographic effects) * Intoxications treated via dialysis * Pregnant, lactating, parturient women * Medical indication for localized citrate anticoagulation * dialysis of less than 12 h * patient or representative refuses to participate
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Centre Hospitalier Universitaire de Nîmes
Nîmes, Gard, 30029, France
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Other studies related to the condition(s) this trial covers.