Iron overload and gum health: new study explores the link
NCT ID NCT04006249
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at whether people with hereditary hemochromatosis (a condition causing too much iron in the body) have higher rates of gum disease. Researchers examined 87 adults aged 35 to 64 with the C282Y gene mutation. They measured gum pocket depth and clinical attachment loss to assess periodontal health. The goal was to understand if hemochromatosis is linked to more severe gum problems.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If this study finds a link, it could lead to better dental screening for people with hemochromatosis.
- What could go wrong
- This is a small, completed observational study, not a treatment trial. It only looks for a connection, so it cannot prove cause or lead to a therapy.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
87 people
The number who actually took part.
- Started
-
Jun 2010
- Finished
-
Dec 2011
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
35 to 64 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients aged 35 to 64 years with homozygosity hemochromatosis C282Y * Patients regularly enrolled in a health insurance plan * Patients with at least 10 natural teeth * Patients who have given informed written, dated and signed consent Exclusion Criteria: * Diabetic patients * Simultaneous participation in another study * Pregnant or lactating women * The incapacitated persons and persons deprived of their liberty * Patients who do not speak French, both written and spoken * Patients previously included in this trial * Patients with heart valves or endovascular equipment (risk of infective endocarditis ...) * Patients with a history of maxillofacial surgery * Patients whose oral status is considered incompatible with entry into the study, at the discretion of the investigator * Patients on drugs that can cause gingival hypertrophy, such as Hydantoins (phenytoin), Dihydropyridines, Diltiazem or Ciclosporin * Patients on medication that can cause gingival bleeding (anticoagulants, antiplatelet agents and aspirin).
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Hemochromatosis are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Rennes University Hospital
Rennes, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.