Heated bleach in root canals: a new way to kill bacteria?
NCT ID NCT07420920
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether heating sodium hypochlorite (a common disinfectant) inside root canals of dead teeth can kill more bacteria and reduce pain afterward. Thirty-six adults with a single dead tooth will receive one of two heating methods or standard cleaning. Researchers will measure bacteria levels before and after treatment and ask about pain levels.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- sodium hypochlorite
- What this could lead to
- If successful, this could point toward a more effective way to disinfect root canals during root canal treatment, potentially reducing infection and pain.
- What could go wrong
- This is a small, early-phase trial with only 36 participants, so results may not apply to everyone. The heating technique may not significantly improve outcomes over standard methods.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1/2
Runs two stages together: safety and dose first, then whether the treatment works.
- Participants
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About 36 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Feb 2026
An estimate. Start dates often move.
- Expected to finish
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Jun 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: For patients: * adult male or female patients * medically free. For selected teeth: * asymptomatic necrotic single rooted teeth * teeth with mature root * restorable teeth. Exclusion Criteria: For patients: * Patients with dental related symptoms * patients with chronic or systemic diseases * pregnant females. For selected teeth: * multirooted teeth * vital teeth * teeth with incompletely formed roots * teeth with internal or external resorption * previously root canal treated teeth
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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Other studies related to the condition(s) this trial covers.