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New obesity drug enters first human tests

NCT ID NCT06845943

Disease control Sponsor: Helicore Biopharma, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused This study
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tests a new drug called HCR-188 in 48 overweight or obese adults to see if it is safe and how the body processes it. Participants receive either the drug or a placebo as injections. The goal is to gather initial safety data, not to treat obesity at this point.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 48 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2025

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Body Mass Index (BMI) of 27 to 40 kg/m2, inclusive * Except for overweight or obese, otherwise healthy as determined by the Investigator * Stable body weight, defined as a \< 5 kg change during the 8 weeks prior to screening * Females of childbearing potential must agree to use highly effective methods of contraception during the participation in the study * Males must be surgically sterile, abstinent, or must agree to use highly effective methods of contraception during participation in the study Exclusion Criteria: * History of or active cardiovascular (CV) disease * History of active pulmonary diseases * History of immunosuppressive, chemotherapeutic, or radiation treatment within the last 12 months prior to Screening * History of malignancy in the past 12 months or active malignancy * History of bariatric surgery or use of gastric balloons * History of diabetes mellitus Type 1 or 2 * History of chronic liver disease * Pregnant or breastfeeding, or a positive pregnancy test at Screening * Treatment with medications that may cause significant weight gain or weight loss

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity and overweight

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Investigative Site

    Herston, Queensland, Australia

More trials for these conditions

Other studies related to the condition(s) this trial covers.