Scientists probe gut bugs for clues to diabetes improvement after surgery
NCT ID NCT05325736
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at how gut bacteria affect blood sugar control after bariatric (weight-loss) surgery. Researchers will compare patients having sleeve gastrectomy, gastric bypass, gallbladder removal, or pancreas sampling. By analyzing stool and blood samples, they hope to understand why blood sugar often improves after surgery. The goal is to gather knowledge, not to test a new treatment.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could reveal how gut bacteria help improve blood sugar after bariatric surgery, pointing toward new non-surgical treatments for diabetes.
- What could go wrong
- This is an observational study, not a treatment trial. It will not directly test a new therapy, and results may not lead to immediate medical advances.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 120 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jul 2021
- Expected to finish
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Jul 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
patients arriving at the outpatient unit at Tel Aviv Sourasky medical center
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * candidates of bariatric surgery or cholecystectomy * age 18-70 * male/female Exclusion Criteria: * previous bariatric surgery * type 1 diabetes * antibiotic treatment 3 months prior to the study * probiotic treatment 3 months prior to the study * chronic disease - gastrointestinal disease, malignancy, psychiatric disorder, endocrinologic disorders * any pathologic findings during endoscopy * participants who will suffer from a post-operation complication
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Souraski medical center
RECRUITINGTel Aviv, Israel
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Weizmann Institute of Science
RECRUITINGRehovot, Israel
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Mapping the hormone behind Post-Surgery blood sugar crashes
- Can collagen supplements help preserve muscle after Weight-Loss surgery?
- Blood markers may predict muscle loss after Weight-Loss surgery
- Can big data reveal why some patients suffer after Weight-Loss surgery?
- Ancient breathing technique could supercharge Post-Surgery fitness
- Can a blood protein predict metabolic changes after gastric bypass?