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Scientists hunt for hidden gut enzymes that break down plant chemicals

NCT ID NCT07589166

Knowledge-focused Sponsor: North Carolina State University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study collected stool samples from 40 healthy adults to search for gut bacteria genes that make enzymes capable of modifying terpenoids and carotenoids—compounds found in plants. Researchers inserted random DNA fragments into E. coli and looked for color changes that signal enzyme activity. The goal was to discover new enzymes and better understand how gut microbes interact with dietary compounds.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help scientists understand how gut bacteria affect our health through processing plant compounds.
What could go wrong
This is a small, early-stage observational study with no direct treatment. It only looks at DNA in a lab, so real-world benefits are uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

40 people

The number who actually took part.

Started

Sep 2025

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Healthy adults

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Body Mass index \<25 Exclusion Criteria: * Pregnant * Taken antibiotics or antifungals in the past 3 months * Taken probiotic supplements in the past 3 months * Diarrhea in the past month

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Carotenoid modifying enzymes Terpene synthases

Contacts and locations

Locations

  • NC State University

    Raleigh, North Carolina, 27606, United States