Gum gaps no more? injections may erase black triangles
NCT ID NCT06314256
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested two injections—hyaluronic acid gel and platelet-rich fibrin (made from your own blood)—to rebuild the small triangle of gum between teeth, often lost due to gum disease or aging. Thirteen healthy adults with moderate gum loss received both treatments in different areas of their mouth. Researchers measured changes in the black triangle size and asked patients which they preferred.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- hyaluronic acid gel and injectable platelet-rich fibrin (i-PRF)
- What this could lead to
- If successful, this could point toward a non-surgical way to fill in black triangles between teeth, improving smile appearance without surgery.
- What could go wrong
- This is a very small, completed Phase 4 trial with only 13 participants, so results may not apply to everyone. The effects may be temporary and require repeat treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
-
13 people
The number who actually took part.
- Started
-
Apr 2024
- Finished
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Jun 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Systemically healthy (without cardiovascular diseases, diabetes, thyroid diseases, auto-immune diseases) * Patients with PPI 2 and PPI 3 papillae according to the Papillary Presence Index classification * Probable pocket depth of 4 mm or less in the relevant area * Plaque index and gingival index in the range of 0-1 * Neighbouring teeth in contact with each other in the relevant area * Absence of any restoration in the relevant area * Non-smoker * No surgical periodontal treatment in the last 6 months * For female subjects not pregnant or lactating * No known allergy to hyaluronic acid Exclusion Criteria: * Not systemically healthy (with cardiovascular diseases, diabetes, thyroid diseases, auto-immune diseases) * Diagnosed with periodontitis * History of allergic reactions to hyaluronic acid * Less than 2 mm keratinized tissue height in the relevant area * Teeth crowding in relevant area * Any kind of restoration (fillings, crowns, etc.) in the relevant area * Smoker * Ongoing orthodontic treatment * Having parafunctional habits (bruxism, etc.)
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Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Altinbas University
Istanbul, Turkey (Türkiye)