Could guava leaves beat traditional mouthwash for healthier gums?
NCT ID NCT07059572
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a mouthwash made from guava leaf extract can reduce plaque and gum inflammation as well as a standard chlorhexidine mouthwash. 160 adults with chronic gingivitis rinsed twice daily for up to 90 days. Researchers measured plaque buildup and gum health to see if the natural option works just as well.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- guava leaf extract mouthwash
- What this could lead to
- If it works, this could offer a natural, affordable alternative to standard mouthwash for managing gum disease.
- What could go wrong
- This is a small, completed trial with 160 participants, so results may not apply to everyone. Guava leaf extract may not be as effective as chlorhexidine, and long-term safety is unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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160 people
The number who actually took part.
- Started
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May 2025
- Finished
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Oct 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 35 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: • Participants with a minimum of 24 functional teeth. * Presence of Plaque induced chronic moderate to severe form of gingivitis. * Participants within the age group of 18 to 35 years. * Willing and able to comply with all study procedures. Exclusion Criteria: • Pregnant or lactating women. * Systemically compromised people; subjects with removable or fixed orthodontic appliances or prosthesis. * People who were prescribed antibiotics or inflammatory drugs in the past 1 month. * History of smoking or any form of tobacco use. * History of allergic reactions to Chlorhexidine or Guava. * Severe systemic conditions that could contraindicate participation in the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Bangabandhu Sheikh Mujib Medical University
Dhaka, Dhaka Division, 1000, Bangladesh